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Neutrophil elastase decreases SARS-CoV-2 spike protein binding to human bronchial epithelia by clipping ACE-2 ectodomain from the epithelial surface.
Kummarapurugu, Apparao B; Hawkridge, Adam M; Ma, Jonathan; Osei, Stephanie; Martin, Rebecca K; Zheng, Shuo; Voynow, Judith A.
Afiliación
  • Kummarapurugu AB; Department of Pediatric Pulmonary Medicine, Children's Hospital of Richmond, Virginia Commonwealth University, Richmond, Virginia, USA. Electronic address: apparao.kummarapurugu@vcuhealth.org.
  • Hawkridge AM; School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia, USA.
  • Ma J; Department of Pediatric Pulmonary Medicine, Children's Hospital of Richmond, Virginia Commonwealth University, Richmond, Virginia, USA.
  • Osei S; Virginia Commonwealth University, Richmond, Virginia, USA.
  • Martin RK; Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
  • Zheng S; Department of Pediatric Pulmonary Medicine, Children's Hospital of Richmond, Virginia Commonwealth University, Richmond, Virginia, USA.
  • Voynow JA; Department of Pediatric Pulmonary Medicine, Children's Hospital of Richmond, Virginia Commonwealth University, Richmond, Virginia, USA.
J Biol Chem ; 299(6): 104820, 2023 06.
Article en En | MEDLINE | ID: mdl-37187291
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Elastasa de Leucocito / Fibrosis Quística / Enzima Convertidora de Angiotensina 2 / COVID-19 Límite: Humans Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Elastasa de Leucocito / Fibrosis Quística / Enzima Convertidora de Angiotensina 2 / COVID-19 Límite: Humans Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article