Several serum lipid metabolites are associated with relapse risk in pediatric-onset multiple sclerosis.
Mult Scler
; 29(8): 936-944, 2023 07.
Article
en En
| MEDLINE
| ID: mdl-37199529
ABSTRACT
BACKGROUND:
The circulating metabolome is altered in multiple sclerosis (MS), but its prognostic capabilities have not been extensively explored. Lipid metabolites might be of particular interest due to their multiple roles in the brain, as they can serve as structural components, energy sources, and bioactive molecules. Gaining a deeper understanding of the disease may be possible by examining the lipid metabolism in the periphery, which serves as the primary source of lipids for the brain.OBJECTIVE:
To determine if altered serum lipid metabolites are associated with the risk of relapse and disability in children with MS.METHODS:
We collected serum samples from 61 participants with pediatric-onset MS within 4 years of disease onset. Prospective longitudinal relapse data and cross-sectional disability measures (Expanded Disability Status Scale [EDSS]) were collected. Serum metabolomics was performed using untargeted liquid chromatography and mass spectrometry. Individual lipid metabolites were clustered into pre-defined pathways. The associations between clusters of metabolites and relapse rate and EDSS score were estimated utilizing negative binomial and linear regression models, respectively.RESULTS:
We found that serum acylcarnitines (relapse rate normalized enrichment score [NES] = 2.1, q = 1.03E-04; EDSS NES = 1.7, q = 0.02) and poly-unsaturated fatty acids (relapse rate NES = 1.6, q = 0.047; EDSS NES = 1.9, q = 0.005) were associated with higher relapse rates and EDSS, while serum phosphatidylethanolamines (relapse rate NES = -2.3, q = 0.002; EDSS NES = -2.1, q = 0.004), plasmalogens (relapse rate NES = -2.5, q = 5.81E-04; EDSS NES = -2.1, q = 0.004), and primary bile acid metabolites (relapse rate NES = -2.0, q = 0.02; EDSS NES = -1.9, q = 0.02) were associated with lower relapse rates and lower EDSS.CONCLUSION:
This study supports the role of some lipid metabolites in pediatric MS relapses and disability.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Esclerosis Múltiple
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Child
/
Humans
Idioma:
En
Revista:
Mult Scler
Asunto de la revista:
NEUROLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos