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Correlative Fluorescent Scanning Probe Nanotomography Used to Study the Intracellular Distribution of Doxorubicin in MCF-7 Human Breast Adenocarcinoma Cells.
Agapova, O I; Efimov, A E; Mochalov, K E; Solovyeva, D O; Gileva, A M; Markvicheva, E A; Yakovlev, D V; Lyundup, A V; Oleinikov, V A; Agapov, I I; Gautier, S V.
Afiliación
  • Agapova OI; Shumakov National Medical Research Center of Transplantology and Artificial Organs, Moscow, Russia. igor_agapov@mail.ru.
  • Efimov AE; Shumakov National Medical Research Center of Transplantology and Artificial Organs, Moscow, Russia.
  • Mochalov KE; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
  • Solovyeva DO; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
  • Gileva AM; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
  • Markvicheva EA; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
  • Yakovlev DV; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
  • Lyundup AV; Рeoples' Friendship University of Russia, Moscow, Russia.
  • Oleinikov VA; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
  • Agapov II; National Research Nuclear University, Moscow, Russia.
  • Gautier SV; Shumakov National Medical Research Center of Transplantology and Artificial Organs, Moscow, Russia.
Dokl Biol Sci ; 509(1): 103-106, 2023 Apr.
Article en En | MEDLINE | ID: mdl-37208575
Developing technologies for efficient targeted drug delivery for oncotherapy requires new methods to analyze the features of micro- and nanoscale distributions of antitumor drugs in cells and tissues. A new approach to three-dimensional analysis of the intracellular distribution of cytostatics was developed using fluorescence scanning optical-probe nanotomography. A correlative analysis of the nanostructure and distribution of injected doxorubicin in MCF-7 human breast adenocarcinoma cells revealed the features of drug penetration and accumulation in the cell. The technology is based on the principles of scanning optical probe nanotomography and is applicable to studying the distribution patterns of various fluorescent or fluorescence-labelled substances in cells and tissues.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Adenocarcinoma Límite: Female / Humans Idioma: En Revista: Dokl Biol Sci Año: 2023 Tipo del documento: Article País de afiliación: Rusia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Adenocarcinoma Límite: Female / Humans Idioma: En Revista: Dokl Biol Sci Año: 2023 Tipo del documento: Article País de afiliación: Rusia