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Altered neurovascular coupling in the children with attention-deficit/hyperactivity disorder: a comprehensive fMRI analysis.
Su, Shu; Zhao, Jing; Dai, Yan; Lin, Liping; Zhou, Qin; Yan, Zi; Qian, Long; Cui, Wei; Liu, Meina; Zhang, Hongyu; Yang, Zhiyun; Chen, Yingqian.
Afiliación
  • Su S; Department of Radiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Zhao J; Department of Radiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Dai Y; Department of Radiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Lin L; Department of Radiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Zhou Q; Department of Radiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Yan Z; Department of Radiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Qian L; Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China.
  • Cui W; Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China.
  • Liu M; Department of Pediatric, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Zhang H; Department of Pediatric, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Yang Z; Department of Radiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. yzhyun@mail.sysu.edu.cn.
  • Chen Y; Department of Radiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. chenyx288@mail.sysu.edu.cn.
Eur Child Adolesc Psychiatry ; 33(4): 1081-1091, 2024 Apr.
Article en En | MEDLINE | ID: mdl-37222790
ABSTRACT
The coupling between resting-state cerebral blood flow (CBF) and blood oxygenation level-dependent (BOLD) signals reflects the mechanism of neurovascular coupling (NVC), which have not been illustrated in attention-deficit/hyperactivity disorder (ADHD). Fifty ADHD and 42 age- and gender-matched typically developing controls (TDs) were enrolled. The NVC imaging metrics were investigated by exploring the Pearson correlation coefficients between CBF and BOLD-derived quantitative maps (ALFF, fALFF, DCP maps). Three types of NVC metrics (CBF-ALFF, CBF-fALFF, CBF-DCP coupling) were compared between ADHD and TDs group, and the inner association between altered NVC metrics and clinical variables in ADHD group was further analyzed. Compared to TDs, ADHD showed significantly reduced whole-brain CBF-ALFF coupling (P < 0.001). Among regional level (all PFDR < 0.05), ADHD showed significantly lower CBF-ALFF coupling in bilateral thalamus, default-mode network (DMN) involving left anterior cingulate (ACG.L) and right parahippocampal gyrus (PHG.R), execution control network (ECN) involving right middle orbital frontal gyrus (ORBmid.R) and right inferior frontal triangular gyrus (IFGtriang.R), and increased CBF-ALFF coupling in attention network (AN)-related left superior temporal gyrus (STG.L) and somatosensory network (SSN))-related left rolandic operculum (ROL.L). Furthermore, increased CBF-fALFF coupling was found in the visual network (VN)-related left cuneus and negatively correlated with the concentration index of ADHD (R = - 0.299, PFDR = 0.035). Abnormal regional NVC metrics were at widespread neural networks in ADHD, mainly involved in DMN, ECN, SSN, AN, VN and bilateral thalamus. Notably, this study reinforced the insights into the neural basis and pathophysiological mechanism underlying ADHD.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Eur Child Adolesc Psychiatry Asunto de la revista: PEDIATRIA / PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Eur Child Adolesc Psychiatry Asunto de la revista: PEDIATRIA / PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: China