IRAK1 inhibition blocks the HIV-1 RNA mediated pro-inflammatory cytokine response from microglia.

Campbell, Grant R; Rawat, Pratima; Teodorof-Diedrich, Carmen; Spector, Stephen A

Campbell, Grant R; Rawat, Pratima; Teodorof-Diedrich, Carmen; Spector, Stephen A.

Afiliación

Campbell GR; Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.
Rawat P; Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Teodorof-Diedrich C; Present address: Microbiologics Inc, San Diego, CA, USA.
Spector SA; Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.

J Gen Virol ; 104(5)2023 05.

Article en En | MEDLINE | ID: mdl-37256770

Asunto(s)

Infecciones por VIH; VIH-1; Humanos; Citocinas/genética; Quinasas Asociadas a Receptores de Interleucina-1/genética; Quinasas Asociadas a Receptores de Interleucina-1/metabolismo; VIH-1/genética; Microglía; Receptor Toll-Like 8; ARN

Palabras clave

HIV; IRAK1; TLR7; TLR8; microglia; pacritinib

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 Límite: Humans Idioma: En Revista: J Gen Virol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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