Single-dose intranasal administration of α-syn PFFs induce lewy neurite-like pathology in olfactory bulbs.
Parkinsonism Relat Disord
; 112: 105440, 2023 Jul.
Article
en En
| MEDLINE
| ID: mdl-37267818
ABSTRACT
INTRODUCTION:
Pathological α-synuclein (α-Syn) propagation may cause Parkinson's disease progression. We aimed to verify whether single-dose intranasal administration of α-Syn preformed fibrils (PFFs) induces α-Syn pathology in the olfactory bulb (OB).METHODS:
A single dose of α-Syn PFFs was administered to the left nasal cavity of wild-type mice. The untreated right side served as a control. The α-Syn pathology of the OBs was examined up to 12 months after the injection.RESULTS:
Lewy neurite-like aggregates were observed in the OB 6 and 12 months after the treatment.CONCLUSIONS:
These findings suggest that pathological α-Syn can propagate from the olfactory mucosa to the OB and reveal the potential dangers of α-Syn PFFs inhalation.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Sinucleinopatías
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Parkinsonism Relat Disord
Asunto de la revista:
NEUROLOGIA
Año:
2023
Tipo del documento:
Article