Novel presynaptic assay system revealed that metformin ameliorates exaggerated synaptic release and Munc18-1 accumulation in presynapses of neurons from Fragile X syndrome mouse model.

Takeda, Renoma; Ishii, Rie; Parvin, Shumaia; Shiozawa, Aki; Nogi, Terukazu; Sasaki, Yukio

Novel presynaptic assay system revealed that metformin ameliorates exaggerated synaptic release and Munc18-1 accumulation in presynapses of neurons from Fragile X syndrome mouse model.

Takeda, Renoma; Ishii, Rie; Parvin, Shumaia; Shiozawa, Aki; Nogi, Terukazu; Sasaki, Yukio.

Afiliación

Takeda R; Functional Structure Science Laboratory, Department of Medical Life Science, Yokohama City University Graduate School of Medical Life Science, 1-7-29 Suehiro-cho, Tsurumi-ward, Yokohama 230-0045, Japan.
Ishii R; Functional Structure Science Laboratory, Department of Medical Life Science, Yokohama City University Graduate School of Medical Life Science, 1-7-29 Suehiro-cho, Tsurumi-ward, Yokohama 230-0045, Japan.
Parvin S; Functional Structure Science Laboratory, Department of Medical Life Science, Yokohama City University Graduate School of Medical Life Science, 1-7-29 Suehiro-cho, Tsurumi-ward, Yokohama 230-0045, Japan.
Shiozawa A; Structural Biology Laboratory, Department of Medical Life Science, Yokohama City University Graduate School of Medical Life Science, 1-7-29 Suehiro-cho, Tsurumi-ward, Yokohama 230-0045, Japan.
Nogi T; Structural Biology Laboratory, Department of Medical Life Science, Yokohama City University Graduate School of Medical Life Science, 1-7-29 Suehiro-cho, Tsurumi-ward, Yokohama 230-0045, Japan.
Sasaki Y; Functional Structure Science Laboratory, Department of Medical Life Science, Yokohama City University Graduate School of Medical Life Science, 1-7-29 Suehiro-cho, Tsurumi-ward, Yokohama 230-0045, Japan. Electronic address: y_sasaki@yokohama-cu.ac.jp.

Neurosci Lett ; 810: 137317, 2023 07 27.

Article en En | MEDLINE | ID: mdl-37286070

Asunto(s)

Síndrome del Cromosoma X Frágil; Animales; Ratones; Modelos Animales de Enfermedad; Proteína de la Discapacidad Intelectual del Síndrome del Cromosoma X Frágil/genética; Proteína de la Discapacidad Intelectual del Síndrome del Cromosoma X Frágil/metabolismo; Síndrome del Cromosoma X Frágil/tratamiento farmacológico; Síndrome del Cromosoma X Frágil/genética; Síndrome del Cromosoma X Frágil/metabolismo; Ratones Noqueados; Neuronas/metabolismo; Sinapsis/fisiología

Palabras clave

Autism; FMRP; Fragile X syndrome; LRRTM2; Local protein synthesis; Metformin; Munc18-1; Presynapse

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Síndrome del Cromosoma X Frágil Límite: Animals Idioma: En Revista: Neurosci Lett Año: 2023 Tipo del documento: Article País de afiliación: Japón

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