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An aerobic exercise intervention to improve metabolic health among people living with HIV with at-risk alcohol use: the ALIVE-Ex research study protocol.
Simon, Liz; Primeaux, Stefany D; Levitt, Danielle E; Bourgeois, Brianna; Johannsen, Neil M; Peters, Adrianna; Ahmed, Jameel; Marshall, Richard H; Fairchild, Alexandra H; Ferguson, Tekeda F; Molina, Patricia E.
Afiliación
  • Simon L; Department of Physiology, LSU Health Sciences Center, 1901 Perdido Street, MEB/7205, New Orleans, LA, 70112, USA.
  • Primeaux SD; Comprehensive Alcohol HIV/AIDS Research Center, LSU Health Sciences Center, New Orleans, LA, 70112, USA.
  • Levitt DE; Department of Physiology, LSU Health Sciences Center, 1901 Perdido Street, MEB/7205, New Orleans, LA, 70112, USA.
  • Bourgeois B; Joint Diabetes, Endocrinology & Metabolism Program, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
  • Johannsen NM; Department of Physiology, LSU Health Sciences Center, 1901 Perdido Street, MEB/7205, New Orleans, LA, 70112, USA.
  • Peters A; Comprehensive Alcohol HIV/AIDS Research Center, LSU Health Sciences Center, New Orleans, LA, 70112, USA.
  • Ahmed J; Department of Kinesiology & Sport Management, Texas Tech University, Lubbock, TX, 79409, USA.
  • Marshall RH; Department of Physiology, LSU Health Sciences Center, 1901 Perdido Street, MEB/7205, New Orleans, LA, 70112, USA.
  • Fairchild AH; Comprehensive Alcohol HIV/AIDS Research Center, LSU Health Sciences Center, New Orleans, LA, 70112, USA.
  • Ferguson TF; School of Kinesiology, Louisiana State University, Baton Rouge, LA, 70803, USA.
  • Molina PE; Department of Physiology, LSU Health Sciences Center, 1901 Perdido Street, MEB/7205, New Orleans, LA, 70112, USA.
AIDS Res Ther ; 20(1): 35, 2023 06 09.
Article en En | MEDLINE | ID: mdl-37296413
ABSTRACT

BACKGROUND:

Effective antiretroviral therapy (ART) in people living with HIV (PLWH) has improved life expectancy and increased risk of age-associated cardiometabolic comorbidities. At-risk alcohol use is more frequent among PLWH and increases the risk of health challenges. PLWH with at-risk alcohol use are more likely to meet criteria for prediabetes/diabetes and this is associated with impaired whole-body glucose-insulin dynamics.

METHODS:

The Alcohol & Metabolic Comorbidities in PLWH Evidence Driven Interventions Study (ALIVE-Ex Study, NCT03299205) is a longitudinal, prospective, interventional study to determine the effects of an aerobic exercise protocol on improving dysglycemia among PLWH with at-risk alcohol use. The intervention is a moderate intensity aerobic exercise protocol implemented 3 days per week for 10 weeks at the Louisiana State University Health Sciences Center-New Orleans. Participants who have a fasting blood glucose level between 94 and 125 mg/dl will be enrolled in the study. Oral glucose tolerance tests, fitness assessments, and skeletal muscle biopsies will be performed pre- and post-exercise intervention. The primary outcome is to determine whether the exercise protocol improves measures of whole-body glucose-insulin dynamics, cardiorespiratory fitness, and skeletal muscle metabolic and bioenergetic function. Secondary outcomes are to determine whether the exercise intervention improves cognitive function and overall quality of life. Results generated will demonstrate the effect of exercise on glycemic measures in PLWH with subclinical dysglycemia and at-risk alcohol use.

CONCLUSIONS:

The proposed intervention will also have the potential to be scalable to promote lifestyle changes among PLWH, particularly in underserved communities.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / Insulinas Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: AIDS Res Ther Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / Insulinas Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: AIDS Res Ther Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos