Photo-crosslinked enhanced double-network hydrogels based on modified gelatin and oxidized sodium alginate for diabetic wound healing.
Int J Biol Macromol
; 245: 125528, 2023 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-37385313
ABSTRACT
The diabetic wound is hard to repair due to bacterial infection, lasting inflammation, and so on. Therefore, it is vital to fabricate a multi-functional hydrogel dressing for the diabetic wound. In this study, a kind of dual-network hydrogel loaded with gentamicin sulfate (GS) based on sodium alginate oxide (OSA) and glycidyl methacrylate gelatin (GelGMA) was designed through the Schiff base bonding and photo-crosslinking to promote the diabetic wound healing. The hydrogels exhibited stable mechanical properties, high water absorbency, and good biocompatibility and biodegradability. Antibacterial results showed that gentamicin sulfate (GS) had a remarkable antibacterial effect on Staphylococcus aureus and Escherichia coli. In a diabetic full-thickness skin wound model, the GelGMA-OSA@GS hydrogel dressing dramatically decreases inflammation and accelerated re-epithelialization and granulation tissue formation, promising applications in promoting diabetic wound healing.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cicatrización de Heridas
/
Diabetes Mellitus
Límite:
Humans
Idioma:
En
Revista:
Int J Biol Macromol
Año:
2023
Tipo del documento:
Article