Single-Component Self-Healing Antibacterial Anti-Inflammatory Intracellular-Antioxidative Poly(itaconic acid-pluronic) Hydrogel for Rapid Repair of MRSA-Impaired Wound.
ACS Appl Mater Interfaces
; 15(28): 33413-33424, 2023 Jul 19.
Article
en En
| MEDLINE
| ID: mdl-37394732
ABSTRACT
The rapid healing and repair of multidrug-resistant bacteria infected wound is still a challenge in the field of wound surgery. It is an effective strategy to develop multifunctional bioactive biomaterials with anti-infection therapy and promoting tissue regeneration. However, most of conventional multifunctional wound healing biomaterials possess the complicated composition and fabrication procedure, which may limit their clinical transformation. Herein, we report a single-component multifunctional bioactive self-healing scaffold (itaconic acid-pluronic-itaconic acid) (FIA) with robust antibacterial antioxidant anti-inflammatory bioactivity for treating methicillin-resistant Staphylococcus aureus (MRSA) impaired wound. FIA scaffolds exhibited the temperature-responsive sol-gel behavior, good injectability, and broad-spectrum antibacterial activity (100% inhibition rate against S. aureus, E. coli, and MRSA). FIA possessed favorable hemocompatibility and cell compatibility and even stimulated the cellular proliferation. FIA could efficiently scavenge the intracellular reactive oxygen species (ROS), decrease the inflammation factors expression, promote endotheliocyte migration and blood tube formation, and reduce the M1 phenotype of macrophages in vitro. FIA could significantly clear the MRSA infection, speed up the MRSA-infected wound healing and rapid formation of the normal epithelial layer and skin appendages. This work may provide a simple and efficient multifunctional bioactive biomaterial strategy for overcoming the challenge of the MRSA-impaired wound.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Staphylococcus aureus Resistente a Meticilina
Idioma:
En
Revista:
ACS Appl Mater Interfaces
Asunto de la revista:
BIOTECNOLOGIA
/
ENGENHARIA BIOMEDICA
Año:
2023
Tipo del documento:
Article
País de afiliación:
China