Synthesis, Biological, Spectroscopic and Computational Investigations of Novel <i>N</i>-Acylhydrazone Derivatives of Pyrrolo[3,4-<i>d</i>]pyridazinone as Dual COX/LOX Inhibitors.

Mikus, Jakub; Swiatek, Piotr; Przybyla, Patrycja; Krzyzak, Edward; Marciniak, Aleksandra; Kotynia, Aleksadra; Redzicka, Aleksandra; Wiatrak, Benita; Jawien, Paulina; Gebarowski, Tomasz; Szczukowski, Lukasz

Synthesis, Biological, Spectroscopic and Computational Investigations of Novel N-Acylhydrazone Derivatives of Pyrrolo[3,4-d]pyridazinone as Dual COX/LOX Inhibitors.

Mikus, Jakub; Swiatek, Piotr; Przybyla, Patrycja; Krzyzak, Edward; Marciniak, Aleksandra; Kotynia, Aleksadra; Redzicka, Aleksandra; Wiatrak, Benita; Jawien, Paulina; Gebarowski, Tomasz; Szczukowski, Lukasz.

Afiliación

Mikus J; Student Science Club of Medicinal Chemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Swiatek P; Department of Medicinal Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Przybyla P; Student Science Club of Medicinal Chemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Krzyzak E; Department of Basic Chemical Sciences, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211a, 50-556 Wroclaw, Poland.
Marciniak A; Department of Basic Chemical Sciences, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211a, 50-556 Wroclaw, Poland.
Kotynia A; Department of Basic Chemical Sciences, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211a, 50-556 Wroclaw, Poland.
Redzicka A; Department of Medicinal Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Wiatrak B; Department of Pharmacology, Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland.
Jawien P; Department of Biostructure and Animal Physiology, Division of Animal Anatomy, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Kozuchowska 1, 51-631 Wroclaw, Poland.
Gebarowski T; Department of Biostructure and Animal Physiology, Division of Animal Anatomy, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Kozuchowska 1, 51-631 Wroclaw, Poland.
Szczukowski L; Department of Medicinal Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.

Molecules ; 28(14)2023 Jul 18.

Article en En | MEDLINE | ID: mdl-37513351

Asunto(s)

Inhibidores de la Ciclooxigenasa; Hidrazonas; Inhibidores de la Lipooxigenasa; Piridazinas; Pirroles; Hidrazonas/síntesis química; Hidrazonas/química; Hidrazonas/farmacocinética; Hidrazonas/farmacología; Inhibidores de la Ciclooxigenasa/síntesis química; Inhibidores de la Ciclooxigenasa/química; Inhibidores de la Ciclooxigenasa/farmacocinética; Inhibidores de la Ciclooxigenasa/farmacología; Piridazinas/síntesis química; Piridazinas/química; Piridazinas/farmacocinética; Piridazinas/farmacología; Pirroles/síntesis química; Pirroles/química; Pirroles/farmacocinética; Pirroles/farmacología; Humanos; Fibroblastos; Simulación por Computador; Permeabilidad de la Membrana Celular; Línea Celular

Palabras clave

AAG; ADME; HSA; NAH; cyclooxygenase; fluorescence spectroscopy; inflammation; lipoxygenase; molecular docking; pyridazinone

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridazinas / Pirroles / Inhibidores de la Lipooxigenasa / Inhibidores de la Ciclooxigenasa / Hidrazonas Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Polonia

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