Genetic distance informs polygenic score predictive accuracy.
Trends Genet
; 39(11): 813-815, 2023 Nov.
Article
en En
| MEDLINE
| ID: mdl-37524625
ABSTRACT
Polygenic scores (PGSs) aggregate the effects of variants across the genome to estimate genetic liability, but have lower performance in external study populations. A new study by Ding et al. has applied a novel framework to estimate the individual-level predictive accuracy of PGSs, and demonstrates that performance reduction occurs linearly with genetic distance.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Trends Genet
Asunto de la revista:
GENETICA
Año:
2023
Tipo del documento:
Article