Polyheterocyclic peptidomimetics: Parallel solid phase synthesis of oligo cyclic guanidines and their inhibition activity against Mycobacterium tuberculosis DNA gyrase.

Tantak, Mukund; Rayala, Ramanjaneyulu; Deng, Zifang; Bunnell, Ashley; Wang, Ting; Chaudhari, Prakash; Leng, Fenfei; Nefzi, Adel

Tantak, Mukund; Rayala, Ramanjaneyulu; Deng, Zifang; Bunnell, Ashley; Wang, Ting; Chaudhari, Prakash; Leng, Fenfei; Nefzi, Adel.

Afiliación

Tantak M; Center for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA.
Rayala R; Center for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA.
Deng Z; Department of Chemistry & Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA.
Bunnell A; Center for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA.
Wang T; Center for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA.
Chaudhari P; Center for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA.
Leng F; Department of Chemistry & Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA.
Nefzi A; Center for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA; Herbert Wertheim College of Medicine, FIU, 11200 SW 8th St, Miami, FL 33199, USA. Electronic address: anefzi@fiu.edu.

Bioorg Med Chem Lett ; 93: 129439, 2023 09 01.

Article en En | MEDLINE | ID: mdl-37557925

Asunto(s)

Mycobacterium tuberculosis; Peptidomiméticos; Tuberculosis; Humanos; Girasa de ADN; Peptidomiméticos/farmacología; Peptidomiméticos/uso terapéutico; Guanidinas; Técnicas de Síntesis en Fase Sólida; Tuberculosis/tratamiento farmacológico; Inhibidores de Topoisomerasa II/farmacología; Inhibidores de Topoisomerasa II/uso terapéutico; Guanidina

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tuberculosis / Peptidomiméticos / Mycobacterium tuberculosis Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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