Characterization of the Pro101Gln mutation that enhances the catalytic performance of T. indicus NADH-dependent d-lactate dehydrogenase.

Liu, Jiongqin; Liu, Gongquan; Han, Xiao; Tao, Fei; Xu, Ping

Liu, Jiongqin; Liu, Gongquan; Han, Xiao; Tao, Fei; Xu, Ping.

Afiliación

Liu J; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Liu G; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Han X; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Tao F; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China. Electronic address: taofei@sjtu.edu.cn.
Xu P; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China. Electronic address: pingxu@sjtu.edu.cn.

Structure ; 31(12): 1616-1628.e3, 2023 12 07.

Article en En | MEDLINE | ID: mdl-37729918

Asunto(s)

L-Lactato Deshidrogenasa; NAD; L-Lactato Deshidrogenasa/genética; L-Lactato Deshidrogenasa/química; L-Lactato Deshidrogenasa/metabolismo; NAD/química; Mutación; Ácido Láctico/química; Ácido Láctico/metabolismo

Palabras clave

NADH-dependent dehydrogenase; adaptive evolution; binding conformation; catalytic performance; d-lactate dehydrogenase; d-lactic acid

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: L-Lactato Deshidrogenasa / NAD Idioma: En Revista: Structure Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China

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