The Effect of Folic Acid Supplementation on Endothelial Function and Arterial Stiffness Markers in Adults: A Systematic Review and Meta-Analysis.
Healthcare (Basel)
; 11(18)2023 Sep 13.
Article
en En
| MEDLINE
| ID: mdl-37761721
ABSTRACT
Folic acid might improve endothelial function, but the results are inconclusive. This systematic review evaluated the effect of folic acid supplementation on endothelial parameters and arterial stiffness in adults. The study protocol was registered with the PROSPERO database (CRD42021290195). The PubMed, Web of Sciences, Cochrane and Scopus databases were searched to identify English-language randomised controlled trials of the effect of folate supplementation on arterial stiffness and endothelial function markers in adults. There were significant differences between the effect of folic acid and placebo on flow-mediated dilation (random-effects model, standardized mean differences (SMD) 0.888, 95% confidence interval (CI) 0.447, 1.329, p < 0.001) and monocyte chemotactic protein 1 (random-effects model, SMD -1.364, 95% CI -2.164, -0.563, p < 0.001), but there was no significant difference in the central pulse wave velocity (fixed-effects model, SMD -0.069, 95% CI -0.264, 0.125, p = 0.485) and peripheral pulse wave velocity (fixed-effects model, SMD -0.093, 95% CI -0.263, 0.077, p = 0.284). In conclusion, folic acid might have a favourable effect on endothelial function but may not affect arterial stiffness. Further studies are needed to confirm these results.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Tipo de estudio:
Clinical_trials
/
Systematic_reviews
Idioma:
En
Revista:
Healthcare (Basel)
Año:
2023
Tipo del documento:
Article
País de afiliación:
Polonia