Novel Escherichia coli-Infecting Bacteriophages Isolated from Uganda That Target Human Clinical Isolates.
Phage (New Rochelle)
; 4(3): 141-149, 2023 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-37841386
ABSTRACT
Background:
The antimicrobial resistance catastrophe is a growing global health threat and predicted to be worse in developing countries. Phages for Global Health (PGH) is training scientists in these regions to isolate relevant therapeutic phages for pathogenic bacteria within their locality, and thus contributing to making phage technology universally available. Materials andMethods:
During the inaugural PGH workshop in East Africa, samples from Ugandan municipal sewage facilities were collected and two novel Escherichia coli lytic phages were isolated and characterized.Results:
The phages, UP19 (capsid diameter â¼100 nm, contractile tail â¼120/20 nm) and UP30 (capsid diameter â¼70 nm, noncontractile tail of â¼170/20 nm), lysed â¼82% and â¼36% of the 11 clinical isolates examined, respectively. The genomes of UP19 (171.402 kb, 282 CDS) and UP30 (49.834 kb, 75 CDS) closely match the genera Dhakavirus and Tunavirus, respectively.Conclusion:
The phages isolated have therapeutic potential for further development against E. coli infections.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Phage (New Rochelle)
Año:
2023
Tipo del documento:
Article
País de afiliación:
Reino Unido