A novel protein encoded by circVPS13D attenuates antiviral innate immunity by targeting MAVS in teleost fish.
J Virol
; 97(11): e0088623, 2023 Nov 30.
Article
en En
| MEDLINE
| ID: mdl-37843373
ABSTRACT
IMPORTANCE The expression of circVPS13D was upregulated with SCRV invasion, which proved that circVPS13D was involved in the regulation of the antiviral immune response. Our study revealed that the existence of circVPS13D promoted the replication of SCRV. Functionally, circVPS13D negatively regulates the antiviral responses of fish. Mechanistically, we confirmed that circVPS13D inhibited RLRs antiviral signaling pathway via the encoded protein VPS13D-170aa by targeting MAVS. Our study provided novel insights into the roles of protein-coding circRNAs and supported VPS13D-170aa as a negative regulator in the antiviral immune responses of teleost fish.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Virosis
/
Proteínas de Peces
/
Proteínas de Transporte Vesicular
/
ARN Circular
Límite:
Animals
Idioma:
En
Revista:
J Virol
Año:
2023
Tipo del documento:
Article
País de afiliación:
China