The dual role of microglia in neuropathic pain after spinal cord injury: Detrimental and protective effects.
Exp Neurol
; 370: 114570, 2023 12.
Article
en En
| MEDLINE
| ID: mdl-37852469
ABSTRACT
Spinal cord injury (SCI) is a debilitating condition that is frequently accompanied by neuropathic pain, resulting in significant physical and psychological harm to a vast number of individuals globally. Despite the high prevalence of neuropathic pain following SCI, the precise underlying mechanism remains incompletely understood. Microglia are a type of innate immune cell that are present in the central nervous system (CNS). They have been observed to have a significant impact on neuropathic pain following SCI. This article presents a comprehensive overview of recent advances in understanding the role of microglia in the development of neuropathic pain following SCI. Specifically, the article delves into the detrimental and protective effects of microglia on neuropathic pain following SCI, as well as the mechanisms underlying their interconversion. Furthermore, the article provides a thorough overview of potential avenues for future research in this area.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Traumatismos de la Médula Espinal
/
Neuralgia
Límite:
Humans
Idioma:
En
Revista:
Exp Neurol
Año:
2023
Tipo del documento:
Article
País de afiliación:
China