Traffic-related air pollution and Parkinson's disease in central California.
Environ Res
; 240(Pt 1): 117434, 2024 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-37858688
ABSTRACT
BACKGROUND:
Prior studies suggested that air pollution exposure may increase the risk of Parkinson's Disease (PD). We investigated the long-term impacts of traffic-related and multiple sources of particulate air pollution on PD in central California.METHODS:
Our case-control analysis included 761 PD patients and 910 population controls. We assessed exposure at residential and occupational locations from 1981 to 2016, estimating annual average carbon monoxide (CO) concentrations - a traffic pollution marker - based on the California Line Source Dispersion Model, version 4. Additionally, particulate matter (PM2.5) concentrations were based on a nationwide geospatial chemical transport model. Exposures were assessed as 10-year averages with a 5-year lag time prior to a PD diagnosis for cases and an interview date for controls, subsequently categorized into tertiles. Logistic regression models were used, adjusting for various factors.RESULTS:
Traffic-related CO was associated with an increased odds ratio for PD at residences (OR for T3 vs. T1 1.58; 95% CI 1.20, 2.10; p-trend = 0.02) and workplaces (OR for T3 vs. T1 1.91; 95% CI 1.22, 3.00; p-trend <0.01). PM2.5 was also positively associated with PD at residences (OR for T3 vs. T1 1.62; 95% CI 1.22, 2.15; p-trend <0.01) and workplaces (OR for T3 vs. T1 1.85; 95% CI 1.21, 2.85; p-trend <0.01). Associations remained robust after additional adjustments for smoking status and pesticide exposure and were consistent across different exposure periods.CONCLUSION:
We found that long-term modeled exposure to local traffic-related air pollution (CO) and fine particulates from multiple sources (PM2.5) at homes and workplaces in central California was associated with an increased risk of PD.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Contaminantes Atmosféricos
/
Contaminación del Aire
/
Contaminación por Tráfico Vehicular
Límite:
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Environ Res
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos