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Evaluation of a New Chemiluminescent Immunoassay-Based Interferon-Gamma Release Assay for Detection of Latent Tuberculosis Infection.
Kim, Keun Ju; Ryu, Seong-Eun; Lee, Ha-Na; Oh, Seung-Hwan; Chang, Chulhun L.
Afiliación
  • Kim KJ; Department of Laboratory Medicine, Korea University College of Medicine, Seoul 02841, Republic of Korea.
  • Ryu SE; Department of Laboratory Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.
  • Lee HN; Department of Laboratory Medicine, Pusan National University Hospital, Busan 49241, Republic of Korea.
  • Oh SH; Department of Laboratory Medicine, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
  • Chang CL; Department of Laboratory Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.
Medicina (Kaunas) ; 59(10)2023 Sep 27.
Article en En | MEDLINE | ID: mdl-37893452
Background and Objectives: This study aimed to evaluate the performance of a new chemiluminescent immunoassay-based tuberculosis (TB) interferon-gamma release assay (IGRA), AdvanSureI3 TB-IGRA (LG Chem Ltd., Seoul, Republic of Korea), for detecting latent tuberculosis infection in comparison with T-SPOT.TB (Oxford Immunotec, Oxford, UK). Materials and Methods: Between June 2021 and December 2021, 125 non-duplicate blood specimens were collected from adult volunteers; each subject received both tests concurrently. Total agreement and Cohen's kappa coefficient (κ) were used to calculate concordance. The Jonckheere-Terpstra test was used to examine the correlation between interferon-gamma (IFN-γ) levels in AdvanSureI3 TB-IGRA and spot counts in T-SPOT.TB. Results: The IGRA findings of the two assays revealed 90.8% (95% confidence interval [CI] = 84.2-94.8) total agreement with κ of 0.740 (95% CI = 0.595-0.885), showing substantial agreement between the two tests. Additionally, the amount of IFN-γ in AdvanSureI3 TB-IGRA increased with the spot counts in T-SPOT.TB (p < 0.001). Conclusions: Our research revealed that the results of the AdvanSureI3 TB-IGRA were comparable to those of T-SPOT.TB.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tuberculosis / Tuberculosis Latente Límite: Adult / Humans Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tuberculosis / Tuberculosis Latente Límite: Adult / Humans Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article