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Identification of circulating proteins associated with general cognitive function among middle-aged and older adults.
Tin, Adrienne; Fohner, Alison E; Yang, Qiong; Brody, Jennifer A; Davies, Gail; Yao, Jie; Liu, Dan; Caro, Ilana; Lindbohm, Joni V; Duggan, Michael R; Meirelles, Osorio; Harris, Sarah E; Gudmundsdottir, Valborg; Taylor, Adele M; Henry, Albert; Beiser, Alexa S; Shojaie, Ali; Coors, Annabell; Fitzpatrick, Annette L; Langenberg, Claudia; Satizabal, Claudia L; Sitlani, Colleen M; Wheeler, Eleanor; Tucker-Drob, Elliot M; Bressler, Jan; Coresh, Josef; Bis, Joshua C; Candia, Julián; Jennings, Lori L; Pietzner, Maik; Lathrop, Mark; Lopez, Oscar L; Redmond, Paul; Gerszten, Robert E; Rich, Stephen S; Heckbert, Susan R; Austin, Thomas R; Hughes, Timothy M; Tanaka, Toshiko; Emilsson, Valur; Vasan, Ramachandran S; Guo, Xiuqing; Zhu, Yineng; Tzourio, Christophe; Rotter, Jerome I; Walker, Keenan A; Ferrucci, Luigi; Kivimäki, Mika; Breteler, Monique M B; Cox, Simon R.
Afiliación
  • Tin A; Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA. atin@umc.edu.
  • Fohner AE; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. atin@umc.edu.
  • Yang Q; Department of Epidemiology, University of Washington, Seattle, WA, USA. afohner@uw.edu.
  • Brody JA; Institute for Public Health Genetics, University of Washington, Seattle, WA, USA. afohner@uw.edu.
  • Davies G; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. afohner@uw.edu.
  • Yao J; Department of Biostatistics, Boston University, Boston, MA, USA.
  • Liu D; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Caro I; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
  • Lindbohm JV; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Duggan MR; Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
  • Meirelles O; University of Bordeaux, Institut National de la Santé et de la Recherche Médicale (INSERM), Bordeaux Population Health Research Center, UMR 1219, CHU Bordeaux, Bordeaux, France.
  • Harris SE; Broad Institute of the Massachusetts Institute of Technology and Harvard University, The Klarman Cell Observatory, Cambridge, MA, USA.
  • Gudmundsdottir V; Clinicum, Department of Public Health, University of Helsinki, Helsinki, Finland.
  • Taylor AM; Department of Epidemiology and Public Health, University College London, London, UK.
  • Henry A; Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA.
  • Beiser AS; National Institute on Aging, National Institutes of Health, Laboratory of Epidemiology and Population Science, Bethesda, MD, USA.
  • Shojaie A; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
  • Coors A; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
  • Fitzpatrick AL; Icelandic Heart Association, Kopavogur, Iceland.
  • Langenberg C; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
  • Satizabal CL; Institute of Cardiovascular Science, University of London, London, UK.
  • Sitlani CM; Department of Biostatistics, Boston University, Boston, MA, USA.
  • Wheeler E; Framingham Heart Study, Framingham, MA, USA.
  • Tucker-Drob EM; Department of Biostatistics, University of Washington, Seattle, WA, USA.
  • Bressler J; Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
  • Coresh J; Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Bis JC; Departments of Family Medicine, University of Washington, Seattle, WA, USA.
  • Candia J; Precision Healthcare Institute, Queen Mary University of London, London, UK.
  • Jennings LL; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Pietzner M; Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Lathrop M; Framingham Heart Study, Framingham, MA, USA.
  • Lopez OL; Department of Population Health Sciences and Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA.
  • Redmond P; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
  • Gerszten RE; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Rich SS; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Heckbert SR; Department of Psychology, University of Texas, Austin, TX, USA.
  • Austin TR; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Hughes TM; Johns Hopkins University, Baltimore, MD, USA.
  • Tanaka T; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Emilsson V; Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
  • Vasan RS; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, USA.
  • Guo X; Precision Healthcare Institute, Queen Mary University of London, London, UK.
  • Zhu Y; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Tzourio C; Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Rotter JI; McGill Genome Centre, Montreal, QC, Canada.
  • Walker KA; Departments of Neurology and Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
  • Ferrucci L; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
  • Kivimäki M; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Breteler MMB; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
  • Cox SR; Department of Epidemiology, University of Washington, Seattle, WA, USA.
Commun Biol ; 6(1): 1117, 2023 11 03.
Article en En | MEDLINE | ID: mdl-37923804
ABSTRACT
Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating proteins and cognitive function. We identify 246 protein measures quantified by the SomaScan assay as associated with cognitive function (p < 4.9E-5, n up to 7289). Of these, 45 were replicated using SomaScan data, and three were replicated using Olink data at Bonferroni-corrected significance. Enrichment analysis linked the proteins associated with general cognitive function to cell signaling pathways and synapse architecture. Mendelian randomization analysis implicated higher levels of NECTIN2, a protein mediating viral entry into neuronal cells, with higher Alzheimer's disease (AD) risk (p = 2.5E-26). Levels of 14 other protein measures were implicated as consequences of AD susceptibility (p < 2.0E-4). Proteins implicated as causes or consequences of AD susceptibility may provide new insight into the potential relationship between immunity and AD susceptibility as well as potential therapeutic targets.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Límite: Aged / Humans / Middle aged Idioma: En Revista: Commun Biol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Límite: Aged / Humans / Middle aged Idioma: En Revista: Commun Biol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos