Interaction between vitamin E intake and a COMT gene variant on colorectal cancer risk among Korean adults: a case-control study.
Epidemiol Health
; 45: e2023100, 2023.
Article
en En
| MEDLINE
| ID: mdl-37974041
ABSTRACT
OBJECTIVES:
Previous human trials have not supported the anticarcinogenic effect of vitamin E despite biological plausibility and considerable epidemiological evidence. A possible explanation for this inconsistency is the interactive effect of the catechol-O-methyltransferase (COMT) gene and supplemental vitamin E on cancer. We examined whether a COMT gene variant modulates the effect of dietary vitamin E intake on colorectal cancer (CRC) risk.METHODS:
In this case-control study of Korean adults (975 cases and 975 age- and sex-matched controls), dietary vitamin E density (mg/1,000 kcal) was measured using a semiquantitative food frequency questionnaire, COMT single nucleotide polymorphism (SNP) rs740603 (A>G) was genotyped, and CRC was verified histologically. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regression models with adjustments for potential confounders.RESULTS:
Higher vitamin E density was associated with a lower risk of CRC (highest vs. lowest quartiles OR, 0.72; 95% CI, 0.55 to 0.96; p-for-trend=0.002). When stratified by COMT SNP rs740603 genotype, the inverse association between vitamin E density and CRC risk was confined to those with at least 1 A allele (≥median vs.CONCLUSIONS:
Our findings support a role for a genetic polymorphism in COMT in modifying the association between dietary vitamin E intake and CRC.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Colorrectales
/
Catecol O-Metiltransferasa
Límite:
Adult
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Epidemiol Health
Año:
2023
Tipo del documento:
Article