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Veronica persica ameliorates acetaminophen-induced murine hepatotoxicity via attenuating oxidative stress and inflammation.
Tian, Wei-Shun; Zhao, Jing; Kim, Myung-Kon; Tae, Hyun-Jin; Kim, In-Shik; Ahn, Dongchoon; Hwang, Hong Pil; Mao, Ming-Xian; Park, Byung-Yong.
Afiliación
  • Tian WS; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, People's Republic of China; College of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, Jeollabuk-do 54596, Republic of Korea.
  • Zhao J; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, People's Republic of China.
  • Kim MK; Department of Food Science and Technology, Jeonbuk National University, Jeonju 54896, Republic of Korea.
  • Tae HJ; College of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, Jeollabuk-do 54596, Republic of Korea.
  • Kim IS; College of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, Jeollabuk-do 54596, Republic of Korea.
  • Ahn D; College of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, Jeollabuk-do 54596, Republic of Korea.
  • Hwang HP; Department of Surgery of Jeonbuk National University Medical School and Hospital, Jeonju 54896, Republic of Korea.
  • Mao MX; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, People's Republic of China.
  • Park BY; College of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, Jeollabuk-do 54596, Republic of Korea. Electronic address: parkb@jbnu.ac.kr.
Biomed Pharmacother ; 169: 115898, 2023 Dec 31.
Article en En | MEDLINE | ID: mdl-37989029
Excess acetaminophen (APAP) commonly causes severe acute liver injury (ALI), characterized by oxidative stress, pro-inflammatory responses, and hepatocyte damage. Veronica persica (VP) is a traditional medicine with antioxidant and anti-inflammatory properties. There is a paucity of information on its medicinal value, especially its potential mechanisms for alleviating ALI. This study aimed to clarify the ameliorative effects and intracellular mechanisms of VP on APAP-induced ALI via attenuating oxidative stress and inflammation. Mice were given VP for 7 days before exposure to APAP (300 mg/kg). The HPLC and radical scavenging assay found that VP contains 12 phenolic acids and 6 flavonoids, as well as show robust antioxidant capacity. In the APAP-induced ALI model, pre-treatment with VP significantly reduces APAP-induced hepatotoxicity by observing improved hepatocyte pathological injury and further confirmed by serum biochemical indicator. Also, the reduction of TUNEL-positive regions and the regulation of Bcl-2-associated X protein indicated that VP attenuates hepatocytotoxicity. Moreover, VP pre-intervention inhibits the formation of liver pro-inflammatory cytokines, the expression of inflammatory response genes, and increases in myeloperoxidase (MPO) in APAP-exposed mice. The elevated reduced glutathione (GSH) levels and decreased oxidative stress markers indicate that VP reduces APAP-promoted oxidative stress. Further study revealed that VP inhibited the phosphorylation of NF-κB/STAT3 cascade, blocked ERK and JNK phosphorylation, and activated AMP-activated protein kinase (AMPK). To sum up, this study demonstrated that VP exists hepatoprotective abilities on APAP-induced ALI, primarily by suppressing the phosphorylation of NF-κB/STAT3 cascade and ERK-JNK and inducing AMPK activation to alleviate oxidative stress and inflammation.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Veronica / Enfermedad Hepática Inducida por Sustancias y Drogas Límite: Animals Idioma: En Revista: Biomed Pharmacother Año: 2023 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Veronica / Enfermedad Hepática Inducida por Sustancias y Drogas Límite: Animals Idioma: En Revista: Biomed Pharmacother Año: 2023 Tipo del documento: Article