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Prolonged Mpox Disease in People With Advanced HIV: Characterization of Mpox Skin Lesions.
O'Shea, Jesse; Zucker, Jason; Stampfer, Samuel; Cash-Goldwasser, Shama; Minhaj, Faisal S; Dretler, Alexandra; Cheeley, Justin; Chaudhuri, Shaoli; Gallitano, Stephanie M; Gunaratne, Shauna; Parkinson, Melissa; Epling, Brian; Morcock, David R; Sereti, Irini; Deleage, Claire.
Afiliación
  • O'Shea J; Mpox Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Zucker J; Division of Infectious Diseases, Columbia University Irving Medical Center, New York, New York.
  • Stampfer S; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
  • Cash-Goldwasser S; Mpox Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Minhaj FS; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Dretler A; Mpox Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Cheeley J; Division of Infectious Diseases, Atlanta and Emory Decatur Hospital, Decatur, Georgia.
  • Chaudhuri S; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
  • Gallitano SM; Division of Infectious Diseases, Columbia University Irving Medical Center, New York, New York.
  • Gunaratne S; Department of Dermatology, Columbia University Irving Medical Center, New York, New York.
  • Parkinson M; Division of Infectious Diseases, Columbia University Irving Medical Center, New York, New York.
  • Epling B; Division of Infectious Diseases, Columbia University Irving Medical Center, New York, New York.
  • Morcock DR; HIV Pathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
  • Sereti I; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
  • Deleage C; HIV Pathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
J Infect Dis ; 229(Supplement_2): S243-S248, 2024 Mar 26.
Article en En | MEDLINE | ID: mdl-38019806
ABSTRACT
We report 3 complicated and prolonged cases of mpox in people with advanced human immunodeficiency virus (HIV) not on antiretroviral therapy (ART) at mpox diagnosis. Multiple medical countermeasures were used, including prolonged tecovirimat treatment and immune optimization with ART initiation. Immunofluorescence of skin biopsies demonstrated a dense immune infiltrate of predominantly myeloid and CD8+ T cells, with a strong type I interferon local response. RNAscope detected abundant replication of monkeypox virus (MPXV) in epithelial cells and dendritic cells. These data suggest that prolonged mpox in people with advanced HIV may be due to ongoing MPXV replication, warranting aggressive medical countermeasures and immune optimization.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades de la Piel / Infecciones por VIH / Mpox Límite: Humans Idioma: En Revista: J Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: Georgia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades de la Piel / Infecciones por VIH / Mpox Límite: Humans Idioma: En Revista: J Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: Georgia