Eyes open on stem cells.
Stem Cell Reports
; 18(12): 2313-2327, 2023 12 12.
Article
en En
| MEDLINE
| ID: mdl-38039972
ABSTRACT
Recently, the murine cornea has reemerged as a robust stem cell (SC) model, allowing individual SC tracing in living animals. The cornea has pioneered seminal discoveries in SC biology and regenerative medicine, from the first corneal transplantation in 1905 to the identification of limbal SCs and their transplantation to successfully restore vision in the early 1990s. Recent experiments have exposed unexpected properties attributed to SCs and progenitors and revealed flexibility in the differentiation program and a key role for the SC niche. Here, we discuss the limbal SC model and its broader relevance to other tissues, disease, and therapy.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Limbo de la Córnea
/
Epitelio Corneal
Límite:
Animals
Idioma:
En
Revista:
Stem Cell Reports
Año:
2023
Tipo del documento:
Article