Asperulosidic Acid Ameliorates Renal Interstitial Fibrosis via Removing Indoxyl Sulfate by Up-Regulating Organic Anion Transporters in a Unilateral Ureteral Obstruction Mice Model.

Wang, Jing; Shi, Birui; Pan, Yueqing; Yang, Zhuan; Zou, Wei; Liu, Menghua

Wang, Jing; Shi, Birui; Pan, Yueqing; Yang, Zhuan; Zou, Wei; Liu, Menghua.

Afiliación

Wang J; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Shi B; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Pan Y; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Yang Z; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Zou W; Changsha Research and Development Center on Obstetric and Gynecologic Traditional Chinese Medicine Preparation, Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410008, China.
Liu M; School of Pharmaceutical Science, University of South China, Hengyang 421001, China.

Molecules ; 28(23)2023 Nov 21.

Article en En | MEDLINE | ID: mdl-38067420

Asunto(s)

Enfermedades Renales; Transportadores de Anión Orgánico; Insuficiencia Renal Crónica; Obstrucción Ureteral; Ratones; Animales; Obstrucción Ureteral/tratamiento farmacológico; Obstrucción Ureteral/metabolismo; Obstrucción Ureteral/patología; Indicán/metabolismo; Transportadores de Anión Orgánico/metabolismo; Enfermedades Renales/tratamiento farmacológico; Enfermedades Renales/etiología; Enfermedades Renales/metabolismo; Riñón; Insuficiencia Renal Crónica/metabolismo; Fibrosis; ARN Mensajero/metabolismo

Palabras clave

OATs; asperulosidic acid; chronic kidney disease; indoxyl sulfate; renal interstitial fibrosis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Obstrucción Ureteral / Transportadores de Anión Orgánico / Insuficiencia Renal Crónica / Enfermedades Renales Límite: Animals Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China

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