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Liberation of host heme by Clostridioides difficile-mediated damage enhances Enterococcus faecalis fitness during infection.
Smith, Alexander B; Specker, Jonathan T; Hewlett, Katharine K; Scoggins, Troy R; Knight, Montana; Lustig, Abigail M; Li, Yanhong; Evans, Kirsten M; Guo, Yingchan; She, Qianxuan; Christopher, Michael W; Garrett, Timothy J; Moustafa, Ahmed M; Van Tyne, Daria; Prentice, Boone M; Zackular, Joseph P.
Afiliación
  • Smith AB; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Specker JT; Department of Chemistry, University of Florida, Gainesville, Florida, USA.
  • Hewlett KK; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Scoggins TR; Department of Chemistry, University of Florida, Gainesville, Florida, USA.
  • Knight M; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Lustig AM; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Li Y; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Evans KM; Tsinghua University School of Medicine, Beijing, China.
  • Guo Y; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • She Q; Department of Chemistry, University of Florida, Gainesville, Florida, USA.
  • Christopher MW; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Garrett TJ; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Moustafa AM; Department of Chemistry, University of Florida, Gainesville, Florida, USA.
  • Van Tyne D; Department of Chemistry, University of Florida, Gainesville, Florida, USA.
  • Prentice BM; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida, USA.
  • Zackular JP; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
mBio ; 15(1): e0165623, 2024 Jan 16.
Article en En | MEDLINE | ID: mdl-38078767
IMPORTANCE: Clostridioides difficile and Enterococcus faecalis are two pathogens of great public health importance. Both bacteria colonize the human gastrointestinal tract where they are known to interact in ways that worsen disease outcomes. We show that the damage associated with C. difficile infection (CDI) releases nutrients that benefit E. faecalis. One particular nutrient, heme, allows E. faecalis to use oxygen to generate energy and grow better in the gut. Understanding the mechanisms of these interspecies interactions could inform therapeutic strategies for CDI.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Clostridioides difficile / Infecciones por Clostridium / Microbioma Gastrointestinal Límite: Humans Idioma: En Revista: MBio Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Clostridioides difficile / Infecciones por Clostridium / Microbioma Gastrointestinal Límite: Humans Idioma: En Revista: MBio Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos