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Site-selective peptide functionalisation mediated via vinyl-triazine linchpins.
Sydenham, Jack D; Seki, Hikaru; Krajcovicova, Sona; Zeng, Linwei; Schober, Tim; Deingruber, Tomas; Spring, David R.
Afiliación
  • Sydenham JD; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK. spring@ch.cam.ac.uk.
  • Seki H; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK. spring@ch.cam.ac.uk.
  • Krajcovicova S; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK. spring@ch.cam.ac.uk.
  • Zeng L; Department of Organic Chemistry, Palacky University in Olomouc, Tr. 17. Listopadu 12, Olomouc, Czech Republic.
  • Schober T; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK. spring@ch.cam.ac.uk.
  • Deingruber T; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK. spring@ch.cam.ac.uk.
  • Spring DR; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK. spring@ch.cam.ac.uk.
Chem Commun (Camb) ; 60(6): 706-709, 2024 Jan 16.
Article en En | MEDLINE | ID: mdl-38108130
ABSTRACT
Herein we introduce 3-vinyl-1,2,4-triazines derivatives as dual-reactive linkers that exhibit selectivity towards cysteine and specific strained alkynes, enabling conjugate addition and inverse electron-demand Diels-Alder (IEDDA) reactions. This approach facilitates site-selective bioconjugation of biologically relevant peptides, followed by rapid and highly selective reactions with bicyclononyne (BCN) reagents.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Péptidos / Triazinas Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Péptidos / Triazinas Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article