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Chronic Stress and Cardiovascular Events: Findings From the CARDIA Study.
Ajibewa, Tiwaloluwa A; Kershaw, Kiarri N; Carr, J Jeffrey; Terry, James G; Gabriel, Kelley Pettee; Carnethon, Mercedes R; Wong, Mandy; Allen, Norrina B.
Afiliación
  • Ajibewa TA; Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address: tiwaloluwa.ajibewa@northwestern.edu.
  • Kershaw KN; Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
  • Carr JJ; Vanderbilt University Medical Center, Nashville, Tennessee.
  • Terry JG; Vanderbilt University Medical Center, Nashville, Tennessee.
  • Gabriel KP; University of Alabama at Birmingham, Birmingham, Alabama.
  • Carnethon MR; Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
  • Wong M; Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
  • Allen NB; Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Am J Prev Med ; 67(1): 24-31, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38143043
ABSTRACT

INTRODUCTION:

Higher levels of perceived stress are associated with adverse cardiovascular health. It is plausible that these associations are attenuated among individuals with positive psychological factors such as social support and health-enhancing behaviors. Therefore, this study examined longitudinal associations of chronic stress with cardiovascular disease (CVD) events, and whether social support and physical activity (PA) modify these associations.

METHODS:

Data from 3,401 adults (mean age 40.2 years; 46.7% Black; 56.2% women) from the Coronary Artery Risk Development in Young Adults (CARDIA) study, with no prior CVD event in 2000-2001 were analyzed. Chronic stress lasting ≥6 months across 5 life domains (work, financial, relationships, health of self, and health of close other) was self-reported. Adjudicated CVD events (fatal/or nonfatal CVD event) were ascertained yearly through 2020. PA and social support were self-reported via questionnaires. Statistical analyses were conducted in 2023 using multivariable stepwise Accelerated Failure Time analysis to assess associations between key study variables.

RESULTS:

The mean chronic stress score was 1.30±1.33 stressors and, by 2020, 220 participants had experienced a CVD event. Chronic stress was associated with lowered survival (time ratio 0.92; 95% CI 0.854-0.989), when adjusted for sociodemographic and lifestyle variables but no longer significant when adjusting for clinical factors. Neither PA nor social support were significant modifiers (all ps>0.05).

CONCLUSIONS:

Chronic stress was associated with the risk of having a CVD event among middle-aged adults, due at least in part to clinical mediators. Studies should continue exploring positive psychosocial and behavioral factors that may modify this association.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Apoyo Social / Estrés Psicológico / Enfermedades Cardiovasculares / Ejercicio Físico Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Prev Med Asunto de la revista: SAUDE PUBLICA Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Apoyo Social / Estrés Psicológico / Enfermedades Cardiovasculares / Ejercicio Físico Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Prev Med Asunto de la revista: SAUDE PUBLICA Año: 2024 Tipo del documento: Article