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Overweight during development dysregulates cellular metabolism and critical genes that control food intake in the prefrontal cortex.
Silva, Severina Cassia de Andrade; de Lemos, Maria Daniele Teixeira; Dos Santos Junior, Osmar Henrique; Rodrigues, Thyago Oliveira; Silva, Tercya Lucidi; da Silva, Aline Isabel; Fiamoncini, Jarlei; Lagranha, Claudia J.
Afiliación
  • Silva SCA; Neuropsychiatry and Behavior Science Graduate Program, Federal University of Pernambuco - CAV, Vitória de Santo Antão, Brazil.
  • de Lemos MDT; Biochemistry and Physiology Graduate Program, Federal University of Pernambuco - CAV, Vitória de Santo Antão, Brazil.
  • Dos Santos Junior OH; Neuropsychiatry and Behavior Science Graduate Program, Federal University of Pernambuco - CAV, Vitória de Santo Antão, Brazil.
  • Rodrigues TO; Gradute Program in Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco - CAV, Vitória de Santo Antão, Brazil.
  • Silva TL; Neuropsychiatry and Behavior Science Graduate Program, Federal University of Pernambuco - CAV, Vitória de Santo Antão, Brazil.
  • da Silva AI; Centro Universitario UNINASSAU, Caruaru, PE, Brazil.
  • Fiamoncini J; Food Research Center, Department of Food Science and Experimental Nutrition, University of São Paulo, São Paulo, SP, Brazil.
  • Lagranha CJ; Neuropsychiatry and Behavior Science Graduate Program, Federal University of Pernambuco - CAV, Vitória de Santo Antão, Brazil; Biochemistry and Physiology Graduate Program, Federal University of Pernambuco - CAV, Vitória de Santo Antão, Brazil; Gradute Program in Nutrition, Physical Activity and Phe
Physiol Behav ; 276: 114453, 2024 Mar 15.
Article en En | MEDLINE | ID: mdl-38159589
ABSTRACT
BACKGROUNDS AND

AIMS:

Childhood obesity is increasing substantially across the world. The World Obesity Federation (WOF) and World Health Organization (WHO) predicted that in 2030 > 1 billion people will be obese, and by 2035 over 4 billion will reach obesity worldwide. According to WHO, the world soon cannot afford the economic cost of obesity, and we need to act to stop obesity acceleration now. Data in the literature supports that the first 1000 days of life are essential in preventing obesity and related adversities. Therefore, using basic research, the present a study that focuses on the immediate effect of overnutrition and serotonin modulation during the lactation period.

METHODS:

Using a neonatal overfeeding model, male Wistar rats were divided into four groups based on nutrition or serotonin modulation by pharmacological treatment up to 22 days of life. Cellular and mitochondrial function markers, oxidative stress biomarkers and mRNA levels of hedonic and homeostatic genes were evaluated.

RESULTS:

Our data showed that overfeeding during lactation decrease NAD/NADH ratio, citrate synthase activity, and increase ROS production. Lipid and protein oxidation were increased in overfed animals, with a decrease in antioxidant defenses, we also observe a differential expression of mRNA levels of homeostatic and hedonic genes. On the contrary, serotonin modulation with selective serotonin reuptake inhibitors treatment reduces harmful effects caused by overnutrition.

CONCLUSION:

Early effects of overnutrition significantly affect the prefrontal cortex at molecular and cellular level, which could mediate obesity-related neurodegenerative dysfunction.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hipernutrición / Obesidad Infantil Límite: Animals / Child / Female / Humans / Male Idioma: En Revista: Physiol Behav Año: 2024 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hipernutrición / Obesidad Infantil Límite: Animals / Child / Female / Humans / Male Idioma: En Revista: Physiol Behav Año: 2024 Tipo del documento: Article País de afiliación: Brasil