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Differential methylation analysis in neuropathologically confirmed dementia with Lewy bodies.
Reho, Paolo; Saez-Atienzar, Sara; Ruffo, Paola; Solaiman, Sultana; Shah, Zalak; Chia, Ruth; Kaivola, Karri; Traynor, Bryan J; Tilley, Bension S; Gentleman, Steve M; Hodges, Angela K; Aarsland, Dag; Monuki, Edwin S; Newell, Kathy L; Woltjer, Randy; Albert, Marilyn S; Dawson, Ted M; Rosenthal, Liana S; Troncoso, Juan C; Pletnikova, Olga; Serrano, Geidy E; Beach, Thomas G; Easwaran, Hariharan P; Scholz, Sonja W.
Afiliación
  • Reho P; Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
  • Saez-Atienzar S; Laboratory of Precision Environmental Health, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
  • Ruffo P; Neuromuscular Diseases Research Section, National Institute on Aging, Bethesda, MD, USA.
  • Solaiman S; Neuromuscular Diseases Research Section, National Institute on Aging, Bethesda, MD, USA.
  • Shah Z; Medical Genetics Laboratory, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
  • Chia R; Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
  • Kaivola K; Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
  • Traynor BJ; Neuromuscular Diseases Research Section, National Institute on Aging, Bethesda, MD, USA.
  • Tilley BS; Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
  • Gentleman SM; Neuromuscular Diseases Research Section, National Institute on Aging, Bethesda, MD, USA.
  • Hodges AK; Neuropathology Unit, Department of Brain Sciences, Imperial College London, London, UK.
  • Aarsland D; Neuropathology Unit, Department of Brain Sciences, Imperial College London, London, UK.
  • Monuki ES; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Newell KL; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Woltjer R; Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
  • Albert MS; Department of Pathology & Laboratory Medicine, School of Medicine, University of California Irvine, Irvine, CA, USA.
  • Dawson TM; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Rosenthal LS; Department of Neurology, Oregon Health & Sciences University, Portland, OR, USA.
  • Troncoso JC; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA.
  • Pletnikova O; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA.
  • Serrano GE; Neuroregeneration and Stem Cell Programs, Institute of Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Beach TG; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Easwaran HP; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Scholz SW; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA.
Commun Biol ; 7(1): 35, 2024 01 05.
Article en En | MEDLINE | ID: mdl-38182665
ABSTRACT
Dementia with Lewy bodies (DLB) is a common form of dementia in the elderly population. We performed genome-wide DNA methylation mapping of cerebellar tissue from pathologically confirmed DLB cases and controls to study the epigenetic profile of this understudied disease. After quality control filtering, 728,197 CpG-sites in 278 cases and 172 controls were available for the analysis. We undertook an epigenome-wide association study, which found a differential methylation signature in DLB cases. Our analysis identified seven differentially methylated probes and three regions associated with DLB. The most significant CpGs were located in ARSB (cg16086807), LINC00173 (cg18800161), and MGRN1 (cg16250093). Functional enrichment evaluations found widespread epigenetic dysregulation in genes associated with neuron-to-neuron synapse, postsynaptic specialization, postsynaptic density, and CTCF-mediated synaptic plasticity. In conclusion, our study highlights the potential importance of epigenetic alterations in the pathogenesis of DLB and provides insights into the modified genes, regions and pathways that may guide therapeutic developments.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad por Cuerpos de Lewy Límite: Aged / Humans Idioma: En Revista: Commun Biol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad por Cuerpos de Lewy Límite: Aged / Humans Idioma: En Revista: Commun Biol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos