Relationship between steroid use and superinfections in SARS-CoV-2 patients. A systematic review and meta-analysis.
Infect Ecol Epidemiol
; 13(1): 2277000, 2023.
Article
en En
| MEDLINE
| ID: mdl-38187166
ABSTRACT
Introduction:
The use of steroids has been proposed as a pharmacological approach to treat the SARS-CoV-2 infection to improve outcomes. However, there are doubts about safety against the development of superinfections and their worse outcomes.Objective:
To establish the relative frequency of superinfection associated with using steroids in patients with SARS-CoV-2 infection. Materials andmethods:
We conducted a systematic literature review and meta-analysis using PRISMA standards in 5 databases (PubMed/Scopus/Cochrane/EMBASE/Google Scholar). The search was carried out between February 2020 and May 2023. The search terms were 'steroids' or 'superinfection' 'and' followed by 'SARS-CoV-2' or 'COVID-19'.Results:
We found 77 studies, but only 10 with 3539 patients were included in the systematic review. All patients developed severe disease. The documented OR for superinfection through the meta-analysis was 1.437 (95% IC 0.869-2.378) with a p-value of 0.158 without showing a risk attributed to steroids and the development of superinfections. In the Funnel-plot analysis, no publication biases were found.Conclusion:
No relationship was found between using steroids and superinfection in patients with SARS-CoV-2.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Tipo de estudio:
Systematic_reviews
Idioma:
En
Revista:
Infect Ecol Epidemiol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Colombia