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The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development.
Röthe, Juliane; Kraft, Robert; Ricken, Albert; Kaczmarek, Isabell; Matz-Soja, Madlen; Winter, Karsten; Dietzsch, André Nguyen; Buchold, Julia; Ludwig, Marie-Gabrielle; Liebscher, Ines; Schöneberg, Torsten; Thor, Doreen.
Afiliación
  • Röthe J; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.
  • Kraft R; Carl-Ludwig-Institute for Physiology, Medical Faculty, Leipzig University, Leipzig, Germany.
  • Ricken A; Institute of Anatomy, Medical Faculty, Leipzig University, Leipzig, Germany.
  • Kaczmarek I; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.
  • Matz-Soja M; Medical Department II - Gastroenterology, Hepatology, Infectious Diseases, Pneumology, University Medical Center, Leipzig, Germany.
  • Winter K; Division of Hepatology, Clinic and Polyclinic for Oncology, Gastroenterology, Hepatology, Infectious Diseases, and Pneumology, University Hospital, Leipzig, Germany.
  • Dietzsch AN; Institute of Anatomy, Medical Faculty, Leipzig University, Leipzig, Germany.
  • Buchold J; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.
  • Ludwig MG; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.
  • Liebscher I; Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Schöneberg T; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.
  • Thor D; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.
Commun Biol ; 7(1): 104, 2024 01 16.
Article en En | MEDLINE | ID: mdl-38228886
ABSTRACT
Glucose homeostasis is maintained by hormones secreted from different cell types of the pancreatic islets and controlled by manifold input including signals mediated through G protein-coupled receptors (GPCRs). RNA-seq analyses revealed expression of numerous GPCRs in mouse and human pancreatic islets, among them Gpr116/Adgrf5. GPR116 is an adhesion GPCR mainly found in lung and required for surfactant secretion. Here, we demonstrate that GPR116 is involved in the somatostatin release from pancreatic delta cells using a whole-body as well as a cell-specific knock-out mouse model. Interestingly, the whole-body GPR116 deficiency causes further changes such as decreased beta-cell mass, lower number of small islets, and reduced pancreatic insulin content. Glucose homeostasis in global GPR116-deficient mice is maintained by counter-acting mechanisms modulating insulin degradation. Our data highlight an important function of GPR116 in controlling glucose homeostasis.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Islotes Pancreáticos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Commun Biol Año: 2024 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Islotes Pancreáticos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Commun Biol Año: 2024 Tipo del documento: Article País de afiliación: Alemania