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Expressions of HuR, Methyl-HuR and Phospho-HuR in Endometrial Endometrioid Adenocarcinoma Are Associated with Clinical Features.
Hotton, Judicaël; Gauchotte, Guillaume; Mougel, Romane; Migliorini, Mégane; Lacomme, Stéphanie; Battaglia-Hsu, Shyue-Fang; Agopiantz, Mikaël.
Afiliación
  • Hotton J; Department of Gynecology and Obstetrics, CHRU de Nancy, Université de Lorraine, 54000 Nancy, France.
  • Gauchotte G; INSERM U1256 NGERE, Université de Lorraine, 54500 Vandœuvre-lès-Nancy, France.
  • Mougel R; INSERM U1256 NGERE, Université de Lorraine, 54500 Vandœuvre-lès-Nancy, France.
  • Migliorini M; Department of Biopathology CHRU of Nancy, Institut de Cancérologie de Lorraine, BBB, CHRU de Nancy, Université de Lorraine, 54511 Vandœuvre-lès-Nancy, France.
  • Lacomme S; Centre de Ressources Biologiques, BB-0033-00035, CHRU de Nancy, 54000 Nancy, France.
  • Battaglia-Hsu SF; INSERM U1256 NGERE, Université de Lorraine, 54500 Vandœuvre-lès-Nancy, France.
  • Agopiantz M; Department of Reproductive Medicine, CHRU de Nancy, Université de Lorraine, 54000 Nancy, France.
Int J Mol Sci ; 25(2)2024 Jan 12.
Article en En | MEDLINE | ID: mdl-38256026
ABSTRACT
HuR regulates cytoplasmic mRNA stability and translatability, with its expression correlating with adverse outcomes in various cancers. This study aimed to assess the prognostic value and pro-oncogenic properties of HuR and its post-translational isoforms methyl-HuR and phospho-HuR in endometrial adenocarcinoma. Examining 89 endometrioid adenocarcinomas, we analyzed the relationship between HuR nuclear or cytoplasmic immunostaining, tumor-cell proliferation, and patient survival. HuR cytoplasmic expression was significantly increased in grade 3 vs. grade 1 adenocarcinomas (p < 0.001), correlating with worse overall survival (OS) (p = 0.02). Methyl-HuR cytoplasmic expression significantly decreased in grade 3 vs. grade 1 adenocarcinomas (p < 0.001) and correlated with better OS (p = 0.002). Phospho-HuR nuclear expression significantly decreased in grade 3 vs. grade 1 adenocarcinomas (p < 0.001) and non-significantly correlated with increased OS (p = 0.06). Cytoplasmic HuR expression strongly correlated with proliferation markers MCM6 (rho = 0.59 and p < 0.001) and Ki67 (rho = 0.49 and p < 0.001). Conversely, these latter inversely correlated with cytoplasmic methyl-HuR and nuclear phospho-HuR. Cytoplasmic HuR expression is a poor prognosis marker in endometrioid endometrial adenocarcinoma, while cytoplasmic methyl-HuR and nuclear phosphoHuR expressions are markers of better prognosis. This study highlights HuR as a promising potential therapeutic target, especially in treatment-resistant tumors, though further research is needed to understand the mechanisms regulating HuR subcellular localization and post-translational modifications.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Carcinoma Endometrioide / Proteína 1 Similar a ELAV Tipo de estudio: Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Carcinoma Endometrioide / Proteína 1 Similar a ELAV Tipo de estudio: Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Francia