Gastrointestinal perforation associated with bevacizumab in metastatic colorectal cancer.
Cancer Rep (Hoboken)
; 7(2): e1952, 2024 02.
Article
en En
| MEDLINE
| ID: mdl-38258341
ABSTRACT
OBJECTIVE:
To investigate the risk factors for gastrointestinal perforation in metastatic colorectal cancer patients receiving bevacizumab.METHODS:
We retrospectively reviewed 217 patients with metastatic colorectal cancer receiving bevacizumab to investigate the risk factors for gastrointestinal perforation. Three patients occurred intestinal perforation after receiving bevacizumab. We analyzed the clinical characteristics of three patients with intestinal perforation.RESULTS:
All patients receiving bevacizumab. Three of 217 patients occurred intestinal perforation after receiving bevacizumab. Patient no. 1 was 70 years old, female, having history of intestinal obstruction. The patient occurred intestinal perforation and ultimately died after receiving bevacizumab. Patient no. 2 was 59 years old, female, having history of intestinal obstruction. The patient occurred intestinal perforation after receiving bevacizumab, and recovered smoothly after symptomatic treatment. Patient no. 3 was 60 years old, female, having history of intestinal obstruction. The patient occurred intestinal perforation and ultimately died after receiving bevacizumab.CONCLUSIONS:
Patients with advanced colorectal cancer receiving bevacizumab are at risk of gastrointestinal perforation. The patient's age, gender and history of bowel obstruction may be associated with gastrointestinal perforation.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias del Recto
/
Neoplasias Colorrectales
/
Neoplasias del Colon
/
Obstrucción Intestinal
/
Perforación Intestinal
Tipo de estudio:
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Cancer Rep (Hoboken)
/
Cancer rep
/
Cancer reports
Año:
2024
Tipo del documento:
Article
País de afiliación:
China