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Hypertensive disorders of pregnancy and cardiovascular disease risk: A Mendelian Randomisation study.
Tschiderer, Lena; van der Schouw, Yvonne T; Burgess, Stephen; Bloemenkamp, Kitty Wm; Seekircher, Lisa; Willeit, Peter; Onland-Moret, N Charlotte; Peters, Sanne Ae.
Afiliación
  • Tschiderer L; Institute of Health Economics, Medical University of Innsbruck, Innsbruck, Austria.
  • van der Schouw YT; Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, the Netherlands.
  • Burgess S; Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, the Netherlands.
  • Bloemenkamp KW; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
  • Seekircher L; Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.
  • Willeit P; MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Onland-Moret NC; Department of Obstetrics, Division Women and Baby, Birth Centre Wilhelmina Children Hospital, University Medical Centre Utrecht, Utrecht, the Netherlands.
  • Peters SA; Institute of Health Economics, Medical University of Innsbruck, Innsbruck, Austria.
Eur Heart J ; 44(Suppl 2)2023 Nov 09.
Article en En | MEDLINE | ID: mdl-38304335
ABSTRACT

Objective:

Observational studies show that hypertensive disorders of pregnancy (HDPs) are related to unfavourable maternal cardiovascular disease (CVD) risk profiles later in life. We investigated whether genetic liability to pre-eclampsia/eclampsia and gestational hypertension is associated with CVD risk factors and occurrence of CVD events.

Methods:

We obtained genetic associations with HDPs from a genome-wide association study and used individual-participant-data from the UK Biobank to obtain genetic associations with CVD risk factors and CVD events (defined as myocardial infarction or stroke). In our primary analysis, we applied Mendelian Randomisation using inverse-variance weighted regression analysis in ever pregnant women. In sensitivity analyses, we studied men and nulligravidae to investigate genetic liability to HDPs and CVD risk without the ability to experience the underlying phenotype.

Results:

Our primary analysis included 221,155 ever pregnant women (mean age 56.8 [SD 7.9]) with available genetic data. Odds ratios for CVD were 1.20 (1.02-1.41) and 1.24 (1.12-1.38) per unit increase in the log odds of genetic liability to pre-eclampsia/eclampsia and gestational hypertension, respectively. Furthermore, genetic liability to HDPs was associated with higher levels of systolic and diastolic blood pressure and younger age at hypertension diagnosis. Sensitivity analyses revealed no statistically significant differences when comparing the findings to those of nulligravidae and men.

Conclusions:

Genetic liability to HDPs is associated with higher CVD risk, lower blood pressure levels, and earlier hypertension diagnosis. Our study suggests similar findings in ever pregnant women, nulligravidae and men, implying biological mechanisms relating to HDPs are causally related to CVD risk.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Preeclampsia / Enfermedades Cardiovasculares / Hipertensión Inducida en el Embarazo / Eclampsia Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Middle aged / Pregnancy Idioma: En Revista: Eur Heart J Año: 2023 Tipo del documento: Article País de afiliación: Austria

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Preeclampsia / Enfermedades Cardiovasculares / Hipertensión Inducida en el Embarazo / Eclampsia Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Middle aged / Pregnancy Idioma: En Revista: Eur Heart J Año: 2023 Tipo del documento: Article País de afiliación: Austria