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Advancing Global Health Surveillance of Mycotoxin Exposures using Minimally Invasive Sampling Techniques: A State-of-the-Science Review.
Jacobson, Tyler A; Bae, Yeunook; Kler, Jasdeep S; Iyer, Ramsunder; Zhang, Runze; Montgomery, Nathan D; Nunes, Denise; Pleil, Joachim D; Funk, William E.
Afiliación
  • Jacobson TA; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
  • Bae Y; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
  • Kler JS; University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.
  • Iyer R; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
  • Zhang R; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
  • Montgomery ND; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
  • Nunes D; Galter Health Sciences Library, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
  • Pleil JD; Department of Environmental Sciences and Engineering, Gillings School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
  • Funk WE; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Environ Sci Technol ; 58(8): 3580-3594, 2024 Feb 27.
Article en En | MEDLINE | ID: mdl-38354120
ABSTRACT
Mycotoxins are a heterogeneous group of toxins produced by fungi that can grow in staple crops (e.g., maize, cereals), resulting in health risks due to widespread exposure from human consumption and inhalation. Dried blood spot (DBS), dried serum spot (DSS), and volumetric tip microsampling (VTS) assays were developed and validated for several important mycotoxins. This review summarizes studies that have developed these assays to monitor mycotoxin exposures in human biological samples and highlights future directions to facilitate minimally invasive sampling techniques as global public health tools. A systematic search of PubMed (MEDLINE), Embase (Elsevier), and CINAHL (EBSCO) was conducted. Key assay performance metrics were extracted to provide a critical review of the available methods. This search identified 11 published reports related to measuring mycotoxins (ochratoxins, aflatoxins, and fumonisins) using DBS/DSS and VTS assays. Multimycotoxin assays adapted for DBS/DSS and VTS have undergone sufficient laboratory validation for applications in large-scale population health and human biomonitoring studies. Future work should expand the number of mycotoxins that can be measured in multimycotoxin assays, continue to improve multimycotoxin assay sensitivities of several biomarkers with low detection rates, and validate multimycotoxin assays across diverse populations with varying exposure levels. Validated low-cost and ultrasensitive minimally invasive sampling methods should be deployed in human biomonitoring and public health surveillance studies to guide policy interventions to reduce inequities in global mycotoxin exposures.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Micotoxinas Tipo de estudio: Screening_studies Límite: Humans Idioma: En Revista: Environ Sci Technol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Micotoxinas Tipo de estudio: Screening_studies Límite: Humans Idioma: En Revista: Environ Sci Technol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos