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A retroviral link to vertebrate myelination through retrotransposon-RNA-mediated control of myelin gene expression.
Ghosh, Tanay; Almeida, Rafael G; Zhao, Chao; Mannioui, Abdelkrim; Martin, Elodie; Fleet, Alex; Chen, Civia Z; Assinck, Peggy; Ellams, Sophie; Gonzalez, Ginez A; Graham, Stephen C; Rowitch, David H; Stott, Katherine; Adams, Ian; Zalc, Bernard; Goldman, Nick; Lyons, David A; Franklin, Robin J M.
Afiliación
  • Ghosh T; Altos Labs-Cambridge Institute of Science, Cambridge CB21 6GP, UK; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AW, UK. Electronic address: writetotanay@gmail.com.
  • Almeida RG; Centre for Discovery Brain Sciences, MS society Edinburgh Centre for MS Research, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
  • Zhao C; Altos Labs-Cambridge Institute of Science, Cambridge CB21 6GP, UK; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AW, UK.
  • Mannioui A; Sorbonne Université, Institut de Biologie Paris-Seine (IBPS), Aquatic Facility, 75005 Paris, France.
  • Martin E; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, 75013 Paris, France.
  • Fleet A; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AW, UK.
  • Chen CZ; Altos Labs-Cambridge Institute of Science, Cambridge CB21 6GP, UK; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AW, UK.
  • Assinck P; Altos Labs-Cambridge Institute of Science, Cambridge CB21 6GP, UK; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AW, UK.
  • Ellams S; Altos Labs-Cambridge Institute of Science, Cambridge CB21 6GP, UK.
  • Gonzalez GA; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AW, UK.
  • Graham SC; Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
  • Rowitch DH; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Department of Paediatrics, University of Cambridge, Cambridge, UK.
  • Stott K; Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK.
  • Adams I; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
  • Zalc B; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, 75013 Paris, France.
  • Goldman N; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome, Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Lyons DA; Centre for Discovery Brain Sciences, MS society Edinburgh Centre for MS Research, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
  • Franklin RJM; Altos Labs-Cambridge Institute of Science, Cambridge CB21 6GP, UK; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AW, UK. Electronic address: rfranklin@altoslabs.com.
Cell ; 187(4): 814-830.e23, 2024 Feb 15.
Article en En | MEDLINE | ID: mdl-38364788
ABSTRACT
Myelin, the insulating sheath that surrounds neuronal axons, is produced by oligodendrocytes in the central nervous system (CNS). This evolutionary innovation, which first appears in jawed vertebrates, enabled rapid transmission of nerve impulses, more complex brains, and greater morphological diversity. Here, we report that RNA-level expression of RNLTR12-int, a retrotransposon of retroviral origin, is essential for myelination. We show that RNLTR12-int-encoded RNA binds to the transcription factor SOX10 to regulate transcription of myelin basic protein (Mbp, the major constituent of myelin) in rodents. RNLTR12-int-like sequences (which we name RetroMyelin) are found in all jawed vertebrates, and we further demonstrate their function in regulating myelination in two different vertebrate classes (zebrafish and frogs). Our study therefore suggests that retroviral endogenization played a prominent role in the emergence of vertebrate myelin.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Retroelementos / Vaina de Mielina Límite: Animals Idioma: En Revista: Cell Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Retroelementos / Vaina de Mielina Límite: Animals Idioma: En Revista: Cell Año: 2024 Tipo del documento: Article