Epigenetic Aging and Musculoskeletal Outcomes in a Cohort of Women Living With HIV.
J Infect Dis
; 229(6): 1803-1811, 2024 Jun 14.
Article
en En
| MEDLINE
| ID: mdl-38366369
ABSTRACT
BACKGROUND:
The relationship between accelerated epigenetic aging and musculoskeletal outcomes in women with HIV (WWH) has not been studied.METHODS:
We measured DNA methylation age using the Infinium MethylationEPIC BeadChip in a cohort from the Women's Interagency HIV Study (n = 190) with measures of bone mineral density (BMD) and physical function. We estimated 6 biomarkers of epigenetic aging-epigenetic age acceleration (EAA), extrinsic EAA, intrinsic EAA, GrimAge, PhenoAge, and DNA methylation-estimated telomere length-and evaluated associations of epigenetic aging measures with BMD and physical function. We also performed epigenome-wide association studies to examine associations of DNA methylation signatures with BMD and physical function.RESULTS:
This study included 118 WWH (mean age, 49.7 years; 69% Black) and 72 without HIV (mean age, 48.9 years; 69% Black). WWH had higher EAA (mean ± SD, 1.44 ± 5.36 vs -1.88 ± 5.07; P < .001) and lower DNA methylation-estimated telomere length (7.13 ± 0.31 vs 7.34 ± 0.23, P < .001) than women without HIV. There were no significant associations between accelerated epigenetic aging and BMD. Rather, measures of accelerated epigenetic aging were associated with lower physical function.CONCLUSIONS:
Accelerated epigenetic aging was observed in WWH as compared with women without HIV and was associated with lower physical function in both groups.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Densidad Ósea
/
Infecciones por VIH
/
Metilación de ADN
/
Epigénesis Genética
Límite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Infect Dis
Año:
2024
Tipo del documento:
Article