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The human factor H protein family - an update.
Sándor, Noémi; Schneider, Andrea E; Matola, Alexandra T; Barbai, Veronika H; Bencze, Dániel; Hammad, Hani Hashim; Papp, Alexandra; Kövesdi, Dorottya; Uzonyi, Barbara; Józsi, Mihály.
Afiliación
  • Sándor N; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.
  • Schneider AE; HUN-REN-ELTE Complement Research Group, Hungarian Research Network, Budapest, Hungary.
  • Matola AT; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.
  • Barbai VH; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.
  • Bencze D; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.
  • Hammad HH; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.
  • Papp A; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.
  • Kövesdi D; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.
  • Uzonyi B; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.
  • Józsi M; HUN-REN-ELTE Complement Research Group, Hungarian Research Network, Budapest, Hungary.
Front Immunol ; 15: 1135490, 2024.
Article en En | MEDLINE | ID: mdl-38410512
ABSTRACT
Complement is an ancient and complex network of the immune system and, as such, it plays vital physiological roles, but it is also involved in numerous pathological processes. The proper regulation of the complement system is important to allow its sufficient and targeted activity without deleterious side-effects. Factor H is a major complement regulator, and together with its splice variant factor H-like protein 1 and the five human factor H-related (FHR) proteins, they have been linked to various diseases. The role of factor H in inhibiting complement activation is well studied, but the function of the FHRs is less characterized. Current evidence supports the main role of the FHRs as enhancers of complement activation and opsonization, i.e., counter-balancing the inhibitory effect of factor H. FHRs emerge as soluble pattern recognition molecules and positive regulators of the complement system. In addition, factor H and some of the FHR proteins were shown to modulate the activity of immune cells, a non-canonical function outside the complement cascade. Recent efforts have intensified to study factor H and the FHRs and develop new tools for the distinction, quantification and functional characterization of members of this protein family. Here, we provide an update and overview on the versatile roles of factor H family proteins, what we know about their biological functions in healthy conditions and in diseases.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas del Sistema Complemento / Factor H de Complemento Límite: Humans Idioma: En Revista: Front Immunol Año: 2024 Tipo del documento: Article País de afiliación: Hungria

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas del Sistema Complemento / Factor H de Complemento Límite: Humans Idioma: En Revista: Front Immunol Año: 2024 Tipo del documento: Article País de afiliación: Hungria