Disruption of the blood-brain barrier is correlated with spike endocytosis by ACE2 + endothelia in the CNS microvasculature in fatal COVID-19. Scientific commentary on "Detection of blood-brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2".

Magro, Cynthia; Tili, Esmerina; Nuovo, Gerard

Magro, Cynthia; Tili, Esmerina; Nuovo, Gerard.

Afiliación

Magro C; Distinguished Professor of Pathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, NY, NY, USA.
Tili E; Department of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Nuovo G; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. nuovo.1@osu.edu.

Acta Neuropathol ; 147(1): 47, 2024 02 27.

Article en En | MEDLINE | ID: mdl-38413411

Asunto(s)

COVID-19; SARS-CoV-2; Humanos; Barrera Hematoencefálica/metabolismo; Enzima Convertidora de Angiotensina 2/metabolismo; Encéfalo/metabolismo; Endocitosis; Microvasos/metabolismo; Unión Proteica

Palabras clave

Blood-brain barrier; Microvasculitis; Spike; Trichrome

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Límite: Humans Idioma: En Revista: Acta Neuropathol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

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