Impact of mental health comorbidity in children and young adults with inflammatory bowel disease: a UK population-based cohort study.
BMJ Open
; 14(2): e080408, 2024 Feb 28.
Article
en En
| MEDLINE
| ID: mdl-38418244
ABSTRACT
OBJECTIVE:
To evaluate the impact of mental health comorbidity in children and young adults with inflammatory bowel disease (IBD).DESIGN:
Retrospective observational study.SETTING:
Representative population, routinely collected primary care data from the UK Optimum Patient Care Research Database (2015-2019).PARTICIPANTS:
Patients with IBD aged 5-25 years with mental health conditions were compared with patients with IBD of the same age without mental health conditions. PRIMARY AND SECONDARY OUTCOMEMEASURES:
Outcomes comprised quality-of-life indicators (low mood, self-harm, parasuicide, bowel symptoms, absence from school or work, unemployment, substance use and sleep disturbance), IBD interventions (medication, abdominal surgery, stoma formation and nutritional supplements) and healthcare utilisation (primary care interactions and hospital admissions).RESULTS:
Of 1943 individuals aged 5-25 years with IBD, 295 (15%) had a mental health comorbidity. Mental health comorbidity was associated with increased bowel symptoms (adjusted incident rate ratio (aIRR) 1.82; 95% CI 1.33 to 2.52), sleep disturbance (adjusted HR (aHR) 1.63; 95% CI 1.02 to 2.62), substance use (aHR 3.63; 95% CI 1.69 to 7.78), primary care interactions (aIRR 1.33; 95% CI 1.12 to 1.58) and hospital admissions (aIRR 1.87; 95%CI 1.29 to 2.75). In individuals ≥18 years old, mental health comorbidity was associated with increased time off work (aHR 1.55; 95% CI 1.21 to 1.99).CONCLUSIONS:
Mental health comorbidity in children and young adults with IBD is associated with poorer quality of life, higher healthcare utilisation and more time off work. It is imperative that affected young patients with IBD are monitored and receive early mental health support as part of their multidisciplinary care. TRIAL REGISTRATION NUMBER The study protocol was specified and registered a priori (ClinicalTrials.gov study identifier NCT05206734).Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Inflamatorias del Intestino
/
Trastornos Relacionados con Sustancias
Límite:
Adolescent
/
Adult
/
Child
/
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
BMJ Open
Año:
2024
Tipo del documento:
Article
País de afiliación:
Reino Unido