[Research advances of prostaglandin E2 receptor 1 (EP1)].
Sheng Li Xue Bao
; 76(1): 105-118, 2024 Feb 25.
Article
en Zh
| MEDLINE
| ID: mdl-38444136
ABSTRACT
Prostaglandin E2 (PGE2) is an important lipid molecule derived from arachidonic acid, which regulates a variety of physiological and pathological activities. Based on the inhibition of inflammatory PGE2 production, non-steroidal anti-inflammatory drugs (NSAIDs) are considered as the most commonly used drugs to treat inflammatory diseases and to relieve fever and pain symptoms. PGE2 mediates its functions via four different G protein-coupled receptors, named EP1-EP4. Though the limited distribution and low PGE2 affinity of EP1, it plays important roles in the maintenance of many physiological functions and homeostasis. Moreover, EP1 is widely involved in the inflammatory response, pain perception and multisystem pathological function regulation. In this review, we will briefly summarize the recent advances on the physiological and pathophysiological function of EP1 and its targeted drugs development.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Dolor
/
Dinoprostona
Límite:
Humans
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Año:
2024
Tipo del documento:
Article
País de afiliación:
China