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Targeting host-specific metabolic pathways-opportunities and challenges for anti-infective therapy.
Konaklieva, Monika I; Plotkin, Balbina J.
Afiliación
  • Konaklieva MI; Department of Chemistry, American University, Washington, DC, United States.
  • Plotkin BJ; Department of Microbiology and Immunology, Midwestern University, Downers Grove, IL, United States.
Front Mol Biosci ; 11: 1338567, 2024.
Article en En | MEDLINE | ID: mdl-38455763
ABSTRACT
Microorganisms can takeover critical metabolic pathways in host cells to fuel their replication. This interaction provides an opportunity to target host metabolic pathways, in addition to the pathogen-specific ones, in the development of antimicrobials. Host-directed therapy (HDT) is an emerging strategy of anti-infective therapy, which targets host cell metabolism utilized by facultative and obligate intracellular pathogens for entry, replication, egress or persistence of infected host cells. This review provides an overview of the host lipid metabolism and links it to the challenges in the development of HDTs for viral and bacterial infections, where pathogens are using important for the host lipid enzymes, or producing their own analogous of lecithin-cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL) thus interfering with the human host's lipid metabolism.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Front Mol Biosci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Front Mol Biosci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos