Myocardial glycophagy flux dysregulation and glycogen accumulation characterize diabetic cardiomyopathy.
J Mol Cell Cardiol
; 189: 83-89, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-38484473
ABSTRACT
Diabetic heart disease morbidity and mortality is escalating. No specific therapeutics exist and mechanistic understanding of diabetic cardiomyopathy etiology is lacking. While lipid accumulation is a recognized cardiomyocyte phenotype of diabetes, less is known about glycolytic fuel handling and storage. Based on in vitro studies, we postulated the operation of an autophagy pathway in the myocardium specific for glycogen homeostasis - glycophagy. Here we visualize occurrence of cardiac glycophagy and show that the diabetic myocardium is characterized by marked glycogen elevation and altered cardiomyocyte glycogen localization. We establish that cardiac glycophagy flux is disturbed in diabetes. Glycophagy may represent a potential therapeutic target for alleviating the myocardial impacts of metabolic disruption in diabetic heart disease.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Diabetes Mellitus
/
Cardiomiopatías Diabéticas
Límite:
Humans
Idioma:
En
Revista:
J Mol Cell Cardiol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Australia