Your browser doesn't support javascript.
loading
Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles.
Faulkes, Chris G; Eykyn, Thomas R; Miljkovic, Jan Lj; Gilbert, James D; Charles, Rebecca L; Prag, Hiran A; Patel, Nikayla; Hart, Daniel W; Murphy, Michael P; Bennett, Nigel C; Aksentijevic, Dunja.
Afiliación
  • Faulkes CG; School of Biological and Behavioural Sciences, Fogg Building, Mile End Road, Queen Mary University of London, London, E1 4NS, UK.
  • Eykyn TR; Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
  • Miljkovic JL; MRC Mitochondrial Biology Unit, University of Cambridge, Keith Peters Building, Cambridge, CB2 0XY, UK.
  • Gilbert JD; School of Biological and Behavioural Sciences, Fogg Building, Mile End Road, Queen Mary University of London, London, E1 4NS, UK.
  • Charles RL; Centre for Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Bart's and the London Faculty of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
  • Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, Keith Peters Building, Cambridge, CB2 0XY, UK.
  • Patel N; Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
  • Hart DW; Centre for Biochemical Pharmacology, William Harvey Research Institute, Bart's and the London Faculty of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
  • Murphy MP; Department of Zoology and Entomology, Mammal Research Institute, University of Pretoria, Pretoria, 0002, South Africa.
  • Bennett NC; MRC Mitochondrial Biology Unit, University of Cambridge, Keith Peters Building, Cambridge, CB2 0XY, UK.
  • Aksentijevic D; Department of Zoology and Entomology, Mammal Research Institute, University of Pretoria, Pretoria, 0002, South Africa.
Nat Commun ; 15(1): 2204, 2024 Mar 27.
Article en En | MEDLINE | ID: mdl-38538579
ABSTRACT
The naked mole-rat Heterocephalus glaber is a eusocial mammal exhibiting extreme longevity (37-year lifespan), extraordinary resistance to hypoxia and absence of cardiovascular disease. To identify the mechanisms behind these exceptional traits, metabolomics and RNAseq of cardiac tissue from naked mole-rats was compared to other African mole-rat genera (Cape, Cape dune, Common, Natal, Mahali, Highveld and Damaraland mole-rats) and evolutionarily divergent mammals (Hottentot golden mole and C57/BL6 mouse). We identify metabolic and genetic adaptations unique to naked mole-rats including elevated glycogen, thus enabling glycolytic ATP generation during cardiac ischemia. Elevated normoxic expression of HIF-1α is observed while downstream hypoxia responsive-genes are down-regulated, suggesting adaptation to low oxygen environments. Naked mole-rat hearts show reduced succinate levels during ischemia compared to C57/BL6 mouse and negligible tissue damage following ischemia-reperfusion injury. These evolutionary traits reflect adaptation to a unique hypoxic and eusocial lifestyle that collectively may contribute to their longevity and health span.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxígeno / Longevidad Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxígeno / Longevidad Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido