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Frequency and the effects of spondyloarthritis-spectrum disorders on the clinical course and management of Takayasu arteritis: an observational retrospective study.
Abacar, Kerem; Kaymaz-Tahra, Sema; Bayindir, Özün; Ince, Burak; Kutu, Muhammet Emin; Yazici, Ayten; Ediboglu, Elif Durak; Demirci-Yildirim, Tuba; Ademoglu, Zeliha; Omma, Ahmet; Yasar-Bilge, Nazife Sule; Kimyon, Gezmis; Kasifoglu, Timuçin; Emmungil, Hakan; Önen, Fatos; Akar, Servet; Cefle, Ayse; Alpay-Kanitez, Nilüfer; Çelik, Selda; Inanç, Murat; Aksu, Kenan; Keser, Gökhan; Direskeneli, Haner; Alibaz-Öner, Fatma.
Afiliación
  • Abacar K; Internal Medicine, Rheumatology, Marmara University, Istanbul, Turkey. keremabacar@hotmail.com.
  • Kaymaz-Tahra S; Internal Medicine, Rheumatology, Sancaktepe Prof. Dr. Ilhan Varank Hospital, Istanbul, Turkey.
  • Bayindir Ö; Internal Medicine, Rheumatology, Ege University, Izmir, Turkey.
  • Ince B; Istanbul Faculty of Medicine, Internal Medicine, Rheumatology, Istanbul University, Istanbul, Turkey.
  • Kutu ME; Internal Medicine, Rheumatology, Bakirköy Sadi Konuk Hospital, Istanbul, Turkey.
  • Yazici A; Internal Medicine, Rheumatology, Kocaeli University, Kocaeli, Turkey.
  • Ediboglu ED; Internal Medicine, Rheumatology, Izmir Katip Çelebi University, Izmir, Turkey.
  • Demirci-Yildirim T; Internal Medicine, Rheumatology, Dokuz Eylül University, Izmir, Turkey.
  • Ademoglu Z; Internal Medicine, Rheumatology, Trakya University, Edirne, Turkey.
  • Omma A; Internal Medicine, Rheumatology, Ankara Sehir Hospital, Ankara, Turkey.
  • Yasar-Bilge NS; Internal Medicine, Rheumatology, Eskisehir Osmangazi University, Eskisehir, Turkey.
  • Kimyon G; Internal Medicine, Rheumatology, Hatay Mustafa Kemal University, Hatay, Turkey.
  • Kasifoglu T; Internal Medicine, Rheumatology, Eskisehir Osmangazi University, Eskisehir, Turkey.
  • Emmungil H; Internal Medicine, Rheumatology, Trakya University, Edirne, Turkey.
  • Önen F; Internal Medicine, Rheumatology, Dokuz Eylül University, Izmir, Turkey.
  • Akar S; Internal Medicine, Rheumatology, Izmir Katip Çelebi University, Izmir, Turkey.
  • Cefle A; Internal Medicine, Rheumatology, Kocaeli University, Kocaeli, Turkey.
  • Alpay-Kanitez N; Internal Medicine, Rheumatology, Koç University, Istanbul, Turkey.
  • Çelik S; Internal Medicine, Rheumatology, Bakirköy Sadi Konuk Hospital, Istanbul, Turkey.
  • Inanç M; Istanbul Faculty of Medicine, Internal Medicine, Rheumatology, Istanbul University, Istanbul, Turkey.
  • Aksu K; Internal Medicine, Rheumatology, Ege University, Izmir, Turkey.
  • Keser G; Internal Medicine, Rheumatology, Ege University, Izmir, Turkey.
  • Direskeneli H; Internal Medicine, Rheumatology, Marmara University, Istanbul, Turkey.
  • Alibaz-Öner F; Internal Medicine, Rheumatology, Marmara University, Istanbul, Turkey.
Clin Rheumatol ; 43(5): 1571-1578, 2024 May.
Article en En | MEDLINE | ID: mdl-38563865
ABSTRACT

OBJECTIVES:

Extravascular findings of Takayasu arteritis (TAK) often share features with the spondyloarthritis (SpA) spectrum of disorders. However, the characteristics of this overlap and its effect on the vascular manifestations of TAK are not fully known. Therefore, we aimed to investigate the frequency of SpA-related features in TAK patients. MATERIAL AND

METHODS:

In this observational retrospective study, 350 patients with TAK classified according to ACR 1990 criteria, from 12 tertiary rheumatology clinics, were included and evaluated for the presence of axSpA, IBD, or psoriasis. Demographic, clinical features, angiographic involvement patterns, disease activity, and treatments of TAK patients with or without SpA were analyzed.

RESULTS:

Mean age was 45.5 ± 13.6 years and mean follow-up period was 76.1 ± 65.9 months. Among 350 patients, 31 (8.8%) had at least one additional disease from the SpA spectrum, 8 had IBD, 8 had psoriasis, and 20 had features of axSpA. In the TAK-SpA group, TAK had significantly earlier disease onset, compared to TAK-without-SpA (p = 0.041). SpA-related symptoms generally preceded TAK symptoms. Biological treatments, mostly for active vasculitis, were higher in the TAK-SpA group (70.9%) compared to TAK-without-SpA (27.9%) (p < 0.001). Vascular involvements were similar in both.

CONCLUSION:

Our study confirmed that diseases in the SpA spectrum are not rare in TAK. Vascular symptoms appeared earlier in such patients, and more aggressive therapy with biological agents was required in the TAK-SpA group, suggesting an association between TAK and SpA spectrum. Key Points • The pathogenesis of Takayasu arteritis is mediated by an MHC class I alelle (HLA-B*52), similar to spondyloarthritis-disorders. • Extravascular findings of Takayasu arteritis are in the spectrum of spondyloarthritis disease. • This frequent coexistence between Takayasu arteritis and spondyloarthritic disorders suggests a relationship rather than a coincidence.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Psoriasis / Enfermedades Inflamatorias del Intestino / Arteritis de Takayasu / Espondiloartritis / Espondiloartritis Axial Límite: Adult / Humans / Middle aged Idioma: En Revista: Clin Rheumatol Año: 2024 Tipo del documento: Article País de afiliación: Turquía

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Psoriasis / Enfermedades Inflamatorias del Intestino / Arteritis de Takayasu / Espondiloartritis / Espondiloartritis Axial Límite: Adult / Humans / Middle aged Idioma: En Revista: Clin Rheumatol Año: 2024 Tipo del documento: Article País de afiliación: Turquía