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Construction of Isoquinolone Scaffolds on DNA via Rhodium(III)-Catalyzed C-H Activation.
Ye, Yusong; Berry, Madeline; Bock, William J; Cheng, Kunpeng; Nair, Sajiv K; Park, Christiana S; Patman, Ryan L; Sakata, Sylvie; Tran-Dubé, Michelle; Donaldson, Joyann S; Yang, Guanyu; Liu, Guansai.
Afiliación
  • Ye Y; HitGen Inc., Building 6, No. 8 Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu 610200, Sichuan P. R. China.
  • Berry M; Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, California 92121, United States.
  • Bock WJ; Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, California 92121, United States.
  • Cheng K; HitGen Inc., Building 6, No. 8 Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu 610200, Sichuan P. R. China.
  • Nair SK; Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, California 92121, United States.
  • Park CS; Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, California 92121, United States.
  • Patman RL; Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, California 92121, United States.
  • Sakata S; Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, California 92121, United States.
  • Tran-Dubé M; Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, California 92121, United States.
  • Donaldson JS; Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, California 92121, United States.
  • Yang G; HitGen Inc., Building 6, No. 8 Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu 610200, Sichuan P. R. China.
  • Liu G; HitGen Inc., Building 6, No. 8 Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu 610200, Sichuan P. R. China.
Org Lett ; 26(16): 3338-3342, 2024 Apr 26.
Article en En | MEDLINE | ID: mdl-38608176
ABSTRACT
Isoquinolone is one of the most common heterocyclic core structures in countless natural products and many bioactive compounds. Here, a highly efficient approach to synthesize isoquinolone scaffolds on DNA via rhodium(III)-catalyzed C-H activation has been described. This chemistry transformation is robust and has shown good compatibility with DNA, which is suitable for DNA-encoded library synthesis.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Rodio / ADN Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Rodio / ADN Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article