Superparamagnetic MoS2@Fe3O4 nanoflowers for rapid resonance-Raman scattering biodetection.
J Mater Sci Mater Electron
; 33(19): 15754-15762, 2022.
Article
en En
| MEDLINE
| ID: mdl-38625216
ABSTRACT
Sensors for rapid and reliable detection of biomolecules are crucial for clinical medical diagnoses. Here, a rapid, ultra-sensitive, magnetic-assisted biosensor based on resonance Raman scattering at MoS2@Fe3O4 composite nanoflowers is presented. Raman shifts and X-ray photoelectron spectra indicated that the composite was formed via Fe-S covalent bonds. Convenient magnetic separations could be performed because of the superparamagnetic Fe3O4 nanoparticles. MoS2 E12g and A1g Raman peaks were used as probe signals for anti-interference immunoassays. The probe unit of the immunoassay also included goat anti-human IgG molecules that were used as the target analyte. Au substrates coupled with the goat anti-human IgG were used as capture units to form sandwich biosensors. Because of the magnetic enrichment, the detection limit was improved by three orders-of-magnitude and the detection time was reduced from 1.5 h to 1 min. Sandwich biosensors using MoS2@Fe3O4 nanoflowers as Raman probes could be very promising sensors for proteins, antigens, and other immunogenic biopolymers, as well as for corpuscular viruses and cells.
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1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Mater Sci Mater Electron
Año:
2022
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Article