Free ribosomal proteins as culprits for nucleolar stress.

Huppertz, Ina

Huppertz, Ina.

Afiliación

Huppertz I; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, 50931 Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany. Electronic address: ina.huppertz@age.mpg.de.

Mol Cell ; 84(8): 1400-1402, 2024 Apr 18.

Article en En | MEDLINE | ID: mdl-38640892

ABSTRACT

ABSTRACT

Nucleolar stress has been consistently linked to age-related diseases. In this issue, Sirozh et al.1 find that the common molecular signature of nucleolar stress is the accumulation of free ribosomal proteins, which leads to premature aging in mice; however, it can be reversed by mTOR inhibition.

Asunto(s)

Nucléolo Celular; Proteínas Ribosómicas; Ratones; Animales; Proteínas Ribosómicas/genética; Proteínas Ribosómicas/metabolismo; Nucléolo Celular/genética; Nucléolo Celular/metabolismo; ARN Ribosómico/metabolismo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Ribosómicas / Nucléolo Celular Límite: Animals Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article

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